TCTR20221001004已完成不适用
The difference in immunogenic responses to COVID-19 vaccines in cancer patients receiving chemotherapy versus non-chemotherapy treatment
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 185
研究概览
简要总结
The chemotherapy group had significantly lower median anti-SARS-CoV-2 S IgG titers compared with those in the non-chemotherapy group (26 vs 237 U/ml, p less than 0.001) - The anti-SARS-CoV-2 S antibody seroconversion rate after vaccination in the chemotherapy group was significantly lower than that in the non-chemotherapy group (78.9% vs 96.5% , p 0.001) - There was no difference in the reported local or systemic adverse events between the chemotherapy and non-chemotherapy groups
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 Years 至 N/A (No limit)（—）
- 性别
- All
入选标准
- •Patients were eligible if they were Thai citizens aged 18 years or older with histologically or cytologically confirmed solid malignancy, in either early or advanced stages. Other inclusion criteria were an Eastern Cooperative Oncology Group (ECOG) performance status score of 0 to 3 and currently receiving systemic anticancer therapy or active surveillance/follow-up within five years after completed cancer treatment.
排除标准
- •Hematologic malignancy, Concurrent chemoradiotherapy, absolute neutrophil count of less than 1500 cells per mcl or platelet count of less than 100,000 per mcl, expected life expectancy of less than 3 months, HIV infection, pregnancy, and breastfeeding.
研究者
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