The Influence of Oxytocin on Pair-bonding and Emotion Regulation
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Neural response to photographs of the partner
研究概览
简要总结
The neuropeptide oxytocin (OXT) has been identified as a key modulator of human social behavior and it has been recently shown that OXT also contributes to pair-bonding in men. However, it is still elusive whether OXT has similar effects in women. In the present study, the investigators examine the effect of intranasal OXT on behavioral ratings of and neural responses to the male partner in female participants. In a second experiment, the modulatory effect of OXT on emotion regulation is investigated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Healthy female volunteers
- •In a heterosexual relationship
排除标准
- •Current or past psychiatric disease
- •Current or past physical illness
- •Psychoactive medication
- •Pregnant or lactating
研究组 & 干预措施
Oxytocin
24 IU Oxytocin (Syntocinon spray), intranasal application 30 min prior to the experiment
干预措施: Syntocinon-Spray (Drug)
Placebo
Intranasal application, containing all ingredients except for the peptide, 3 puffs per nostril
干预措施: Syntocinon-Spray (Drug)
结局指标
主要结局
Neural response to photographs of the partner
时间窗: About one hour after the intranasal administration of oxytocin
Neural responses will be measured by using functional magnetic resonance imaging (fMRI). In the fMRI analysis the effect of oxytocin on the neural response to the photograph of the partner will be compared with placebo.
Neural response during the regulation of food craving
时间窗: About one hour after the intranasal administration of oxytocin
Neural responses will be measured by using functional magnetic resonance imaging (fMRI). In the fMRI analysis the effect of oxytocin on the neural response to the regulation of food craving will be compared with placebo.
次要结局
- Food craving ratings(About one hour after the intranasal administration of oxytocin)
- Attractiveness ratings of all stimuli(About one hour after the intranasal administration of oxytocin)
- Arousal ratings of all stimuli(About one hour after the intranasal administration of oxytocin)
研究者
Rene Hurlemann
Antragsteller und verantwortlicher Leiter
University Hospital, Bonn