Refining Cough Skill Training in Parkinson's Disease and Dysphagia
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 23
- 试验地点
- 1
- 主要终点
- Change in Peak Expiratory Flow Rate
研究概览
简要总结
Airway protection deficits (cough and swallowing) are prevalent and pervasive in Parkinson's disease (PD), contributing to adverse health outcomes like pneumonia. This study aims to refine cough skill training by examining whether variable versus constant practice conditions improve cough outcomes in people with PD. In addition, this study will provide insight into optimal respiratory adaptations that occur during training to support cough effectiveness, resulting in immediately translatable treatments to improve airway protection-related health outcomes in people with neurodegenerative disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •40 years of age or older
- •have dysphagia as documented by a penetration-aspiration score > 2 on a flexible endoscopic evaluation of swallowing
- •have cough disorder as defined as a maximal voluntary cough peak flow < 5 L/s
- •have no history of other neurological disorders, head and neck cancer, respiratory disease, smoking within 5 years, uncontrolled hypertension, or allergy to capsaicin (reflex cough stimulus)
排除标准
- •unable to participate due to neuropsychological dysfunction (i.e., dementia with a score of < 19 on the Montreal Cognitive Assessment)
- •actively participating in other cough or swallowing treatments
研究组 & 干预措施
Cough Skill Training
During cough skill training, participants will be seated in front of a computer with real-time visualization of their cough waveform. A target line will be provided, and participants will be instructed to perform a single voluntary cough so that their peak flow is within the target's range. Participants will be instructed to continue the cough training regardless of initial accuracy.
干预措施: Cough Skill Training - with Variable Practice (Behavioral)
结局指标
主要结局
Change in Peak Expiratory Flow Rate
时间窗: Before to after two sessions of cough variable practice training over two weeks
Cough Strength
次要结局
- Change in Respiratory Kinematics, specifically lung volume excursion(Before to after two sessions of cough variable practice training over two weeks)
研究者
Michelle Troche
Associate Professor, Lab Director
Teachers College, Columbia University