The Effect of Sensory-enhanced Beverages on Satiety Following Repeated Exposures
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- Change in energy intake
研究概览
简要总结
The study will be a 3-way crossover design: it will assess the impact of consuming a beverage enhanced with satiety-relevant properties on subjective ratings of appetite and on energy intake compared with a low energy version with the same sensory characteristics, and a non-sensory enhanced high energy control.
In addition, saliva samples will be collected at regular intervals for the identification of novel biomarkers of energy intake.
详细描述
The study will be a 3-way crossover design: it will assess the impact of a high-energy, sensory-enhanced beverage on energy intake through ad libitum food consumption and subjective feeling of appetite using visual analogue scales (VAS) compared to 2 control beverages following repeated exposures. Each participant will consume each beverage 10 times. This includes 2 satiety-testing sessions on site at Leatherhead Food Research, and 8 occasions consuming the product as a mid-morning snack during the participants' normal routine. Each participant will attend the Nutrition Unit on 6 different occasions (plus one screening visit) before and after repeated exposures to the beverages at home. The order in which participants receive the beverages will be counterbalanced and randomised. There will be a two-week washout period in which none of the beverages are consumed between the different beverage manipulations. Participants will fast overnight before each visit and consume the same evening meal before each test day. Participants will be instructed to avoid consuming food or calorific beverages for one hour before or after consuming the beverage. Following the last satiety testing day participants will be debriefed and open questions will be asked about experiences of the beverages in a focus group format.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Gender: male or female
- •Age at start of the study ≥ 18 and ≤ 65 years
- •Body Mass Index (BMI) ≥ 18 and ≤ 29.9 kg/m2
- •Apparently healthy: measured by questionnaire (APPENDIX 3): no reported current or previous metabolic diseases or chronic gastrointestinal disorders
- •Reported dietary habits: no medically prescribed diet, no slimming diet, used to eating 3 meals a day
- •Reported intense sporting activities ≤ 10h/w
- •Reported alcohol consumption ≤14 units/w
- •Informed consent signed
- •Recruitment form filled out
排除标准
- •Dislike, allergy or intolerance to test products or study meals
- •Possible eating disorder (measured by SCOFF questionnaire score >1)
- •Reported medical treatment that may affect eating habits/satiety
- •Eating habits questionnaire score >14
- •Reported participation in another biomedical trial 1 month before the start of the study
- •Food allergies or intolerance to ad libitum meals
- •Pregnant and/or breast feeding
研究组 & 干预措施
High energy, low sensory
Mango-flavour beverage
干预措施: Mango-flavour beverage (Behavioral)
Low energy, high sensory
Mango-flavour beverage
干预措施: Mango-flavour beverage (Behavioral)
High energy, high sensory beverage
Mango-flavour beverage
干预措施: Mango-flavour beverage (Behavioral)
结局指标
主要结局
Change in energy intake
时间窗: Weeks 0,3,5,8,10 and 13
Change in intake (kcals) at an ad libitum lunch, assessed before and after the repeated exposure period for each of the 3 beverage products
次要结局
- Change in subjective appetite ratings(Weeks 0,3,5,8,10 and 13)