Neurogenic Inflammatory Response in Peri-implant and Periodontal Diseases Assessed by Biochemical Analysis of the Neuropeptides in Gingival Crevicular Fluid.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 39
- 主要终点
- Gingival crevicular fluid/peri-implant sulcular fluid Level of Substance-P
研究概览
简要总结
Regulatory effects of some neuropeptides substance-P (SP), neurokinin-A (NKA), calcitonin gene-linked peptide (CGRP) and neuropeptide-Y (NPY) )on inflammatory responses in periodontal disease has been described; however, the impact of neuropeptide levels are not clearly defined in healthy and diseased peri-implant tissues.ın order to evaluate the situation, thirty-nine implants that have been loaded over the past 12 months and their symmetrically matching teeth were evaluated using a split-mouth study design. Clinical periodontal examinations included the Silness-Löe plaque index, Löe-Silness gingival index, bleeding on probing, probing pocket depth and clinical attachment level parameters were determined. Gingival crevicular fluid (GCF)/Periimplant sulcular fluid (PISF) samples were collected, and the levels of the neuropeptides were determined by enzyme-linked immunosorbent assay. Correlations between GCF/PISF neuropeptide levels and the clinical examination parameters were evaluated in the peri-implant/periodontal soft tissues.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •The main inclusion criteria for patient selection were as follows:
- •Compliance with systematic maintenance care;
- •Adult, non-smoker, systemically healthy
- •Not using any medicament for the last 6 months ;
- •Partially dentated patient treated with implant-supported metal ceramic full crowns and/or fixed partial dentures
- •As the study was split-mouth designed, in each individual at least one implant and one matching tooth in the same mouth symmetrically representing the same tooth group (premolars/molars);
- •A single type of metal ceramic implant restoration that is functional for at least 1 year; and a matching tooth with no dental or endodontic restorations.
排除标准
- •Medical history of cancer, rheumatoid arthritis, diabetes mellitus, or cardiovascular disease and any other systemic disease affecting lipid metabolism (i.e. impaired glucose tolerance, metabolic syndrome);
- •Compromised immune system;
- •Pregnancy, menopause, or lactation;
- •Ongoing drug therapy that might affect the clinical characteristics of periodontitis and lipid metabolism;
- •Dental treatment during the 6 months prior to data collection.
结局指标
主要结局
Gingival crevicular fluid/peri-implant sulcular fluid Level of Substance-P
时间窗: 8-10 am on the day following periodontal status assessment.
Substance-P (SP) is a neuropeptide of the tachykinin family and marker of neurogenic inflammation.
Gingival crevicular fluid/peri-implant sulcular fluid Level of Calcitonin gene-related peptide
时间窗: 8-10 am on the day following periodontal status assessment.
Calcitonin gene-related peptide (CGRP), another neuropeptide derived from peptidergic nerves and a marker of neurogenic inflammation.
Gingival crevicular fluid/peri-implant sulcular fluid Level of neurokinin-A
时间窗: 8-10 am on the day following periodontal status assessment.
Neurokinin-A is a neuropeptide of the tachykinin family and marker of neurogenic inflammation.
次要结局
未报告次要终点
研究者
muge lutfioglu
assoc. prof.dr
Ondokuz Mayıs University