Staphylococcus Aureus Colonization in Atopic Dermatitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 114
- 试验地点
- 1
- 主要终点
- Difference in rectal and nasal S. aureus colonization rates in a population of children with atopic dermatitis
研究概览
简要总结
The purpose of this study is to characterize the bacterial strains that colonize children with atopic dermatitis.
The investigators hypothesize that rectal cultures will be more sensitive than anterior nares cultures for detecting S. aureus colonization, and that strains of S. aureus colonizing patients with atopic dermatitis will be resistant to commonly used topical antibiotic ointments.
详细描述
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by pruritis and eczematous lesions with a worldwide prevalence of 15-20%. The burden of disease is highest in the most developed nations and predominantly affects children, with 50% of cases arising in the first year of life, and most others arising in the first 5 years. There is a well-known increased susceptibility to skin infection with S. aureus in patients with AD, and such infections are associated with clinical deterioration. While it is routine to evaluate for S. aureus colonization in the anterior nares, there is recent evidence suggesting that rectal colonization may be more significant. The significance of colonization site has not been evaluated in the AD population.
Additionally, while topical antibiotics are a mainstay of treatment in AD, there is no routine data on the resistance to these agents.
Our aim is to characterize the S. aureus colonization patterns in children with AD, including site of colonization and antibiotic resistance. We will analyze routinely-collected skin culture specimens from children with AD seen at our center and determine antibiotic susceptibility profiles. The significance of colonization site will be analyzed.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- — 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •subjects with a diagnosis of atopic dermatitis seen by the Columbia University Medical Center department of dermatology
- •subjects ages 0 to 18 years
排除标准
- •those patients in which a definitive diagnosis of AD cannot be made
- •subjects over the age of 18 years old
- •subjects with evidence of acute systemic illness
- •subjects currently taking systemic antibiotics
- •subjects with viral or fungal skin infection
- •any individual who declines participation
结局指标
主要结局
Difference in rectal and nasal S. aureus colonization rates in a population of children with atopic dermatitis
时间窗: Up to 3 years
次要结局
- Rates of resistance to commonly used topical antibiotic ointments in strains of S. aureus that colonize a population of children with atopic dermatitis(Up to 20 years)