NCT03900663Unknown不适用
Nutritional Status and Body Composition of Children in Relation to Mode of Delivery and Feeding in the First 2 Years of Life
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 主要终点
- Obesity
研究概览
简要总结
- Feeding and growth during infancy have been associated with later life body mass index.
- Breastfeeding seems to have a small but consistent protective effect against obesity in children.
- The Cholesterol content of human milk is 6-fold greater than that of the standard infant formulas.
- Infants delivered by caesarean section may be at increased risk of childhood obesity and adulthood obesity.
详细描述
- Previous guidelines recommended that infants who are exclusively breast fed for the first 6 months of life, with particular solid foods gradually introduced from 6 months associated with lower childhood fat mass.
- The stated reason for discouraging introduction of solids to infant before 4 months include the risk of excessive weight gain, vulnerability of the gut to infection and increased susceptibility to the development of allergic disease.
- Infants whose dietary pattern was most similar to feeding guidelines, with high frequencies of fresh fruit and vegetables, home prepared foods and breast milk, gained weight and skin fold thickness more rapidly from 6 to12 months than other infants, independent of milk feeding, age of introduction of solids and maternal factors.
- Exclusively breastfed infants had significantly higher Total Cholesterol (TC) level and Low density Lipoprotein level (LDL) and lower High density lipoprotein level (HDL) as compared to mixed-fed infants in the first 6 months of life.
- Exclusive breast feeding seems to have a protective effect against some risk factors for cardiovascular disease in later life, as those who exclusively breastfed had lower level of plasma low density lipoprotein (LDL) cholesterol conc., higher level of high density lipoprotein (HDL) and lower LDL/HDL ratio than those bottle fed.
- Early weaning is related to rapid weight gain in infancy, and this may have implication for childhood obesity.
- Vaginally delivered children are colonised with bacterial strains from the mothers' vagina during delivery in contrast to children delivered by CS, and these differences seem to persist throughout infancy.
- The gut microbiota may have a role in energy harvesting, hence inoculation with maternal microbiota through vaginal delivery may be protective for childhood overweight compared with delivery by CS.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 2 Years 至 3 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Infants of both sexes
- •Infants from 2 to 3 years
- •Breast fed or formula fed or mixed fed infants
排除标准
- •Children less than 2 and more than 3 years ago.
- •Children having family history of chronic illness
- •Children having family history of metabolic
- •Children fed cow milk or buffalo milk.
- •Infants delivered preterm.
结局指标
主要结局
Obesity
时间窗: Through one year
Body mass index (BMI) kg/m2
次要结局
未报告次要终点
研究者
MR Rassmy
Pediatric Resident
Assiut University
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