JPRN-UMIN000024291已完成1 期
Phase I study of cord blood transplantation with intra-bone marrow injection of mesenchymal stromal cells - Phase I study of cord blood transplantation with intra-bone marrow injection of mesenchymal stromal cells
Department of Hematology and Oncology, Nagoya University Graduate School of Medicine0 个研究点目标入组 6 人开始时间: 2016年12月1日最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 6
研究概览
简要总结
Five adult patients received MSC-CBT, and no adverse events related to intra-BM injection of MSCs were observed. All patients achieved neutrophil, reticulocyte, and platelet recoveries, with median times to recoveries of 21, 35, and 38 days, respectively. Grade II-IV acute GVHD did not develop in MSC-CBT patients. No patients developed chronic GVHD. At 1 year after transplantation, all MSC-CBT patients survived without relapse.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 20years-old 至 ot applicable（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •1. Positive for HIV-Ab 2. Administration of gemtuzumab ozogamicin within 6 months 3. In pregnancy or breast-feeding 4. Uncontrolled psychiatric disorder 5. Uncontrolled infectious disease 6. Allergy to drugs for transplant preconditioning or GVHD prophylaxis 7. Re-transplantation within 1 year from the preceding transplantation 8. Doctor's decision
研究者
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