Improvised Explosive Device (IED) Level Blasting of Human Blood With Slosh Prevention
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Lysis of blood cells
研究概览
简要总结
To monitor changes in indicators of red cell damage such as extracellular hemoglobin, potassium (K-ABL), and lactate dehydrogenase (LD) post blast exposure.
详细描述
Traumatic brain injury (TBI) causes significant morbidity and mortality, accompanied by high related costs. Recent hypotheses concerning the pathophysiology of TBI invoke Strain Shear Theory and Cavitation Theory. The invbestigators propose to test the importance of the latter by directing blast waves into containers that are either partially or completely filled with blood and measuring markers of lysis.
These experiments are designed to better understand the demonstrated effectiveness of mild jugular compression according to the principle of the Queckenstedt Maneuver to reduce the likelihood of TBI by filling up the compliance of the cranial space. A device (C-Collar) is being developed by Q30 Labs, LLC (Q30), to accomplish this effect.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •• Normal healthy volunteer
- •Able to provide written consent
- •Must be 18 years or older
排除标准
- •• Unable to provide written consent
- •Recent penetrating brain trauma (within 6 months)
- •Under the age of 18 years
研究组 & 干预措施
subject blood drawns
subjects will have blood drawn which will then be exposed to blast via CO2 cartridge
干预措施: blood draw (Other)
结局指标
主要结局
Lysis of blood cells
时间窗: within 2 hours
measure the lysis of blood cells exposed to blast from CO2 cartridge
次要结局
未报告次要终点