Volatile Non-Invasive Biomarkers of Epileptic Seizures
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 270
- 试验地点
- 2
- 主要终点
- Distinguishing epileptic from non-epileptic seizures
研究概览
简要总结
Breath and sweat samples will be collected from people who have been admitted to hospital after a potential seizure and analysed by the team. The researchers then hope to identify a pattern of small molecules that can distinguish seizures from other events, and perhaps determine the severity of the seizure.
详细描述
Determining whether someone has had an epileptic seizure, or another event, can be challenging and result in the wrong diagnosis. A 'seizure test' used after the event would therefore be very helpful.
Researchers have used small molecules released from the body in breath and sweat to detect cancers and other diseases; this study will determine whether a similar method can be used to detect whether someone has had an epileptic seizure.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who have been admitted to either University College London's Queen's Square EEG-telemetry unit or Chalfont Centre for Epilepsy, for diagnosis of seizure events.
- •Patients aged 18 years or above
排除标准
- •Patients with active infection or who have taken antibiotics within 4 weeks
- •Patients on immunosuppressive medications
- •Patients with co-morbidities preventing breath collection
- •Patients unable to provide informed consent.
结局指标
主要结局
Distinguishing epileptic from non-epileptic seizures
时间窗: 3 years
To distinguish epileptic from non-epileptic seizures with the detection of volatile organic compounds (VOCs) in breath and sebum samples.
次要结局
未报告次要终点
研究者
Eleonora Lugara
Dr
University College London Hospitals