Effects of 3mA HD-tDCS on Associative and Working Memory in Cognitively Intact Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 42
- 试验地点
- 2
- 主要终点
- Object Location Touchscreen Task (Version C) Free Recall Average Error
研究概览
简要总结
As we age, a number of factors can reduce our cognitive (or thinking) abilities. This study will evaluate whether transcranial electrical stimulation (TES), which uses small amounts of electricity to modulate brain functioning, can improve cognitive abilities. Here, the effects of TES on working memory, learning, and memory, will be evaluated in a group of healthy older adults.
详细描述
The primary objective is to investigate the cognitive effects of high definition anodal tDCS (HD-tDCS; anode at center electrode) at 3 mA (for 20 minutes) on learning, memory, and working memory. Participants will be randomized to active or sham stimulation and will complete a series of cognitive tests both during and after stimulation.
Tolerability and blinding will also be evaluated using standard side effect questionnaires.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Individuals with intact cognitive functioning.
- •Participants will be age 50 or older.
排除标准
- •Individuals with a documented history of cognitive impairment.
- •A history of serious mental illness (e.g., bipolar disorder, schizophrenia, axis 2 disorders)
- •Sensory or motor impairments that limit the ability to take part in the study
- •A significant history or current use of alcohol or drug abuse/dependence
- •Those who are currently pregnant (if there is a question of pregnancy, pregnancy tests will be available for participants at no charge)
- •Participants with an Mini Mental State Examination score <24 at screening.
研究组 & 干预措施
Active HD-tDCS
Participants will receive "real" HD-tDCS (3 milliamps for 20 minutes) for a single session.
干预措施: Active HD-tDCS (Device)
Sham HD-tDCS
Participants will undergo the exact same procedures as the active group but will receive sham stimulation for a single session.
干预措施: Sham HD-tDCS (Device)
结局指标
主要结局
Object Location Touchscreen Task (Version C) Free Recall Average Error
时间窗: 15 minutes after encoding
The Object Location Touchscreen Task (OLTT) is a measure of object location association memory. The OLTT requires participants to learn and recall the location of 15 object-location associations. Memory is evaluated using a touchscreen monitor, which allows for the continuous measurement of memory accuracy (i.e., distance from targeted location). During the Free Recall, participants are given a blank screen and asked to touch the area of the screen an object was located. Average Score is the average error across all 15 trials. Lower scores represent better performance.
Object Location Touchscreen Task (Version C) Free Recall Average Time to Respond
时间窗: 15 minutes after encoding
The Object Location Touchscreen Task (OLTT) is a measure of object location association memory. The OLTT requires participants to learn and recall the location of 15 object-location associations. Memory is evaluated using a touchscreen monitor, which allows for the continuous measurement of memory accuracy (i.e., distance from targeted location). During the Free Recall, participants are given a blank screen and asked to touch the area of the screen an object was located. Average Time is the average latency to respond across all 15 trials. Lower scores represent faster responses.
Object Location Touchscreen Task (Version C) Cued Recall Average Error
时间窗: 15 minutes after encoding
The Object Location Touchscreen Task (OLTT) requires participants to learn and recall the location of 15 object-location associations. Memory is evaluated using a touchscreen monitor, which allows for the continuous measurement of memory accuracy (i.e., distance from targeted location). During the Cued Recall, participants are shown the "room" or environment on the screen and asked to touch the area of the screen an object was located. Average Score is the average error across all 15 trials. Lower scores represent better performance.
Object Location Touchscreen Task (Version C) Free Recall Total Error
时间窗: 15 minutes after encoding
The Object Location Touchscreen Task (OLTT) is an ecologically relevant measure of object location association memory. The OLTT requires participants to learn and recall the location of 15 object-location associations. Memory is evaluated using a touchscreen monitor, which allows for the continuous measurement of memory accuracy (i.e., distance from targeted location). During the Free Recall, participants are given a black screen and asked to touch the area of the screen an object was located. Total Score is the sum of error for all 15 trials. Lower scores represent better performance.
Object Location Touchscreen Task (Version C) Recognition Average Time to Respond
时间窗: 15 minutes after encoding
The Object Location Touchscreen Task (OLTT) requires participants to learn and recall the location of 15 object-location associations. Memory is evaluated using a touchscreen monitor, which allows for the continuous measurement of memory accuracy (i.e., distance from targeted location). During the Recognition, participants are asked to select the correct location of an object from three options on the screen. Recognition Average Response Time is the average latency to respond across all 15 trials. Lower scores represent faster responses.
Calculated Working Memory Performance Accounting for Simple Attention (Semantic 2-back d' Minus 0-back d')
时间窗: 30 minutes post-stimulation
The n-back is a well validated measure of working memory. During 0-back, participants are asked to respond by pressing a key when the picture on the screen is the same as the given target (e.g., a cow). During Semantic 2-back, participants are asked to respond when a picture shown is in the same semantic category as the picture two items ago (e.g., both fruits). Discriminability (d') is a measure of signal detection that accounts for signal to noise ratio. By subtracting the 0-back d', the calculated score represents a more pure working memory measure. Scores closer to zero or positive represent better working memory performance.
Object Location Touchscreen Task (Version C) Recognition Total Correct
时间窗: 15 minutes after encoding
The Object Location Touchscreen Task (OLTT) requires participants to learn and recall the location of 15 object-location associations. Memory is evaluated using a touchscreen monitor, which allows for the continuous measurement of memory accuracy (i.e., distance from targeted location). During the Recognition, participants are asked to select the correct location of an object from three options on the screen. Recognition total is the number of correct selections on all 15 trials. Higher scores represent better performance.
Performance (d') on a Working Memory (2-back) Test
时间窗: 30 minutes post-stimulation
The n-back is a well validated measure of working memory. During 2-back, participants are asked to respond when a picture shown is the exact same as two items ago. Discriminability (d') is a measure of signal detection that accounts for signal to noise ratio. Higher scores represent better discriminability.
Object Location Touchscreen Task (Version C) Cued Recall Total Error
时间窗: 15 minutes after encoding
The Object Location Touchscreen Task (OLTT) requires participants to learn and recall the location of 15 object-location associations. Memory is evaluated using a touchscreen monitor, which allows for the continuous measurement of memory accuracy (i.e., distance from targeted location). During the Cued Recall, participants are shown the "room" or environment on the screen and asked to touch the area of the screen an object was located. Total Score is the sum of error for all 15 trials. Lower scores represent better performance.
Object Location Touchscreen Task (Version C) Cued Recall Average Time to Respond
时间窗: 15 minutes after encoding
The Object Location Touchscreen Task (OLTT) requires participants to learn and recall the location of 15 object-location associations. Memory is evaluated using a touchscreen monitor, which allows for the continuous measurement of memory accuracy (i.e., distance from targeted location). During the Cued Recall, participants are shown the "room" or environment on the screen and asked to touch the area of the screen an object was located. Average Time is the average latency to respond across all 15 trials. Lower scores represent faster responses.
Performance (d') on a Simple Attention (0-back) Test
时间窗: 30 minutes post-stimulation
The n-back is a well validated measure of working memory. During 0-back, participants are asked to respond by pressing a key when the picture on the screen is the same as the given target (e.g., a cow). Discriminability (d') is a measure of signal detection that accounts for signal to noise ratio. Higher scores represent better discriminability.
Performance (d') on a Working Memory (Semantic 2-back) Test
时间窗: 30 minutes post-stimulation
The n-back is a well validated measure of working memory. During Semantic-back, participants are asked to respond when a picture shown is in the same semantic category as the picture two items ago (e.g., both fruits). Discriminability (d') is a measure of signal detection that accounts for signal to noise ratio. Higher scores represent better discriminability.
Calculated Working Memory Performance Accounting for Simple Attention (2-back d' Minus 0-back d')
时间窗: 30 minutes post-stimulation
The n-back is a well validated measure of working memory. During 0-back, participants are asked to respond by pressing a key when the picture on the screen is the same as the given target (e.g., a cow). During 2-back, participants are asked to respond when a picture shown is the exact same as two items ago. Discriminability (d') is a measure of signal detection that accounts for signal to noise ratio. By subtracting the 0-back d', the calculated score represents a more pure working memory measure. Scores closer to zero or positive represent better working memory performance.
次要结局
- Frequency of Endorsement (%) for Scalp Pain Item in Active and Sham Participants Undergoing HD-tDCS Session(~1 minute post stimulation)
- Blinding in Total Sample(~1 minute post stimulation)
- Frequency of Endorsement (%) for Burning Item in Active and Sham Participants Undergoing HD-tDCS Session(~1 minute post stimulation)
- Frequency of Endorsement (%) for Skin Redness Item in Active and Sham Participants Undergoing HD-tDCS Session(~1 minute post stimulation)
- Frequency of Endorsement (%) for Neck Pain Item in Active and Sham Participants Undergoing HD-tDCS Session(~1 minute post stimulation)
- Frequency of Endorsement (%) for Headache Item in Active and Sham Participants Undergoing HD-tDCS Session(~1 minute post stimulation)
- Frequency of Endorsement (%) for Sleepiness Item in Active and Sham Participants Undergoing HD-tDCS Session(~1 minute post stimulation)
- Frequency of Endorsement (%) for Tingling Item in Active and Sham Participants Undergoing HD-tDCS Session(~1 minute post stimulation)
- Frequency of Endorsement (%) for Concentration Changes Item in Active and Sham Participants Undergoing HD-tDCS Session(~1 minute post stimulation)
- Frequency of Endorsement (%) for Mood Changes Item in Active and Sham Participants Undergoing HD-tDCS Session(~1 minute post stimulation)
- Frequency of Endorsement (%) for Itching Item in Active and Sham Participants Undergoing HD-tDCS Session(~1 minute post stimulation)
研究者
Benjamin Hampstead, PhD
Associate Professor
University of Michigan