Evaluation of Intubation Conditions With the Use of Atracurium After a Fixed Three-minute Delay
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Intubation condition
研究概览
简要总结
The purpose of this study is to evaluate intubation conditions with the use of atracurium after a fixed three-minute delay
详细描述
The recommended dose of a non-depolarizing curare to facilitate tracheal intubation is twice the active dose 95 (the dose that reduces muscle force by 95%). At this dosage, curarization of the laryngeal adductors allowing relaxation and abduction (opening) of the vocal cords is considered certain. With atracurium, the dose for intubation is 0.5 mg.kg-1 and the time to full effect is approximately 3 minutes. With the use of newer hypnotics, there are no data evaluating the conditions for intubation after a fixed time of 3 minutes as with current anesthetic practices.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Adult female
- •Patient to undergo general anesthesia with intubation for scheduled gynecological surgery
- •Patient informed about the study and not opposed to it
排除标准
- •Patients with severe and morbid obesity (BMI>35kg/m2)
- •Pregnancy
- •Patients with difficult intubation
- •Allergy to atracurium and to any other drug used.
- •Patient under tutorship / curatorship
- •Not affiliated with social insurance
- •Patient with AME
结局指标
主要结局
Intubation condition
时间窗: 3 minutes after atracurium injection
The intubating conditions were evaluated on the basis of the consensus conference on Good Clinical Research Practice in Pharmacodynamic Studies of Neuromuscular Blocking Agents. The score used include the following variables: (1) ease of laryngoscopy, (2) vocal cord position, and (3) reaction to the insertion of the endotracheal tube and the cuff inflation (eg, diaphragmatic movement due to patient cough). Each of these variables was rated as (1) excellent, (2) good, or (3) poor. Intubating conditions were scored as excellent if all variables were excellent; the score was good if at least 1 variable was good and the rest were excellent; the conditions were considered poor if any of the variables was rated poor. Evaluation of intubation conditions with the use of atracurium after a fixed three-minute delay
次要结局
未报告次要终点