Pre-anesthesia Pleth Variability Index as a Predictor for Post-induction Hypotension in Elderly Patients Undergoing General Anesthesia: A Prospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 85
- 试验地点
- 1
- 主要终点
- The accuracy (Area under receiver operating characteristic curves) of pre-induction PVI for prediction of post-induction hypotension
研究概览
简要总结
Hypotension after induction of general anesthesia and before surgical stimulation is a prevalent anesthesia-related side effect. The post-induction hypotension disrupts organ perfusion and may cause organ damage particularly acute kidney injury, cerebrovascular stroke, and myocardial ischemia. Post-induction hypotension occurs with greater frequency and severity in the elderly. This is because of aged-related diminished cardiac reserve and impaired autonomic homeostasis. Pleth variability index (PVI) is a software program that measures the dynamic changes of the PI that occurs during a complete respiratory cycle. Our primary outcome is to determine the predictive ability and the optimal cut-off value of pre-anesthesia PVI for predicting elderly patients who are at risk of developing post-induction hypotension
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 90 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with ASA physical status I or II
- •patients will receive general anesthesia
排除标准
- •Patients with a history of cardiorespiratory disorders
- •patients with uncontrolled hypertension or cardiac dysrhythmias
- •Patients with renal or hepatic diseases.
- •Patients with long-standing diabetes and peripheral vascular diseases.
结局指标
主要结局
The accuracy (Area under receiver operating characteristic curves) of pre-induction PVI for prediction of post-induction hypotension
时间窗: before induction of general anesthesia
次要结局
未报告次要终点
研究者
Abeer Ahmed, MD
Assistant Professor of Anesthesia, SICU & pain management. Kasralainy Faculty of medicine
Cairo University