Sleep positional therapy for the treatment of nocturnal gastroesophageal reflux

Amsterdam UMC0 个研究点目标入组 45 人开始时间: 待定最近更新: 2024年2月28日

试验速览

暂无简介。

•Written informed consent.
•-Both male and female patients will be included.
•-Age above 18 years.
•-Symptoms of heartburn and/or acid regurgitation at least 2 times a week during the night.
•-A total reflux symptom score =8 (measured through the GERDQ questionnaire score).
•-Minimal of 1.5% esophageal acid exposure during the night.

•-Surgery of the GI tract other than appendectomy or cholecystectomy.
•-Use of any medication with a potential effect on gastrointestinal motility, secretion or sensitivity that cannot be stopped for the duration of the study (e.g. H2-blockers, antidepressants, prokinetics).
•-History of gastrointestinal cancer.
•-Known diabetes.
•-Regular use of sleep medication (benzodiazepines) that cannot be stopped.
•-Severe and clinically unstable concomitant disease (e.g. liver, cardiovascular or lung disease, neurological or psychiatric disorders, cancer or AIDS and other endocrine disorders).
•-Pregnant or lactating women. Women will be asked if they are pregnant.
•-Patients that sleep >75% of Total Sleep Time (TST) on their left side
•-Patients that sleep <10% of TST on their right side

发起方

Amsterdam UMC