Study Aiming to Measure the Impact on Immune Activation and Inflammatory Markers of Switching From a Triple Combination Antiretroviral Therapy (cART) to a Long Acting Dual Therapy in HIV-infected Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Evolution the trajectory of immune activation and inflammatory markers
研究概览
简要总结
The purpose of the study is to measure the impact on immune activation and inflammatory markers of switching from a triple combination antiretroviral therapy (cART) to a long acting dual therapy in HIV-infected patients
详细描述
Patients meeting the inclusion criteria will be offered to participate to the study.
In case of acceptance by given their writting consent, 6 ml of blood will be collected for measuring immune activation and inflammatory markers, during the blood test scheduled for the routine follow-up.
Six months after cART change, an equal volume of blood will be collected for measuring the same immune activation and inflammatory markers
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients agreeing to participate to the study and to collect their data
- •HIV-1 infected subjects
- •Patients switching from a stable (at least 6 months) and successful triple cART to a long acting dual cART
- •Patients older than 18 yrs and regularly followed in Cannes and Nice hospitals
- •Patients with a healthcare card
排除标准
- •HIV-2 infected subjects
- •Patients not being on successful and stable cART
- •Patients having being treated during acute HIV-infection
- •Patients modifying cART for virological failure
- •Subjects modifying their treatment for another combination than from a triple cART to a dual cART
- •Patients modifying cART during the 6 months of follow-up
- •Patients refusing to participate to the study
- •Patients included in an interventional study during the 6 months of follwo-up
- •Patient under juridical procedure
结局指标
主要结局
Evolution the trajectory of immune activation and inflammatory markers
时间窗: Baseline and 6 months after modiyfying cART
Assess the trajectory of immune activation and inflammatory markers change at 6 month after modifying cART
次要结局
- Prevalence of patients with successful cART(1 month, 3 month, 6 month)