Absorption of Different Forms of Vitamin K From Dairy Products
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- serum vitamin K levels: phylloquinone, menaquinone-7,-8,-9,and -10
研究概览
简要总结
Lactic acid bacteria produce a mixture of higher menaquinones, including menaquinone-9 (MK-9) and menaquinone-10 (MK-10). Vitamin K1 (phylloquinone) is normally present in chloroplasts in green vegetables. A new dairy product is developed containing both vitamin K1 and K2-vitamins. However, the extent to which the various forms of vitamin K are absorbed from such a mixture is not known. In this study the absorption profile of phylloquinone and menaquinones from this new dairy product containing several K-vitamins is investigated. This study describes a dietary intervention experiment for one single cocktail containing several K-vitamins as part of a dairy product.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy men and women between 20 and 45 years old
- •Subjects of normal body weight and height according to BMI < 30
- •Subjects of Caucasian race
- •Subject has given written consent to take part in the study
排除标准
- •Subjects with (a history of) metabolic or gastrointestinal disease
- •Subjects presenting chronic degenerative and/or inflammatory disease
- •Abuse of drugs and/or alcohol
- •Subjects receiving corticoid treatment
- •Subjects using oral anticoagulants
研究组 & 干预措施
vitamin K-rich dairy product
one single intake of a dairy product containing several K-vitamins: phylloquinone, menaquinone-7,8,9-and 10.
干预措施: vitamin K-rich dairy product (Dietary Supplement)
结局指标
主要结局
serum vitamin K levels: phylloquinone, menaquinone-7,-8,-9,and -10
时间窗: one single intake
次要结局
- distribution of vitamin K-forms over lipoprotein fractions: triglyceride rich lipoprotein (TGRLP), intermediate-density lipoprotein (IDL), low-density lipoprotein (LDL), high density lipoprotein (HDL) as well as the lipoprotein-free fraction (LPF)(one single intake)