The Effect of Vitamin A With and Without Zinc and Multivitamin Supplementation on Malaria Morbidity in Ghanaian Children
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 547
- 试验地点
- 1
- 主要终点
- Incidence of clinical malaria attacks
研究概览
简要总结
The aim of this study was to determine the effect of combining vitamin A (VA), zinc (Z) and multivitamins (MV- A, B1, B2, B6, B12, C, D and E) on malaria morbidity
详细描述
A total of 542 children aged between 6-59 months received either: (i) VA (control) or (ii) VA & Z (VAZ) or (iii) VA, Z & MV (VAZM). VA was delivered as a single dose while MV and Z were delivered daily. Malaria cases were managed by community health workers, who used rapid diagnostic test to confirm infection prior to treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •under 5years
- •will stay in the community for 10years
排除标准
- •chronic diseases
研究组 & 干预措施
Vitamin A and zinc
A single dose of 20,000IU Vitamin A and 10mg of elemental zinc each day for 5 months
干预措施: Vitamin A and ZInc (Dietary Supplement)
Vitamin A , Zinc and Multivitamin
A single dose of 20,000IU Vitamin A , 10mg of elemental zinc each day and 0.5ml/kg multivitamin syrup for 5 months
干预措施: Vitamin A , Zinc and Multivitamin (Dietary Supplement)
Vitamin A
A single dose of 20,000IU Vitamin A for the whole study period
干预措施: Vitamin A (Dietary Supplement)
结局指标
主要结局
Incidence of clinical malaria attacks
时间窗: Baseline and every month up to six months
While taking the supplement, malaria incidence will be measured
次要结局
- Incidence of diarrhea attacks(Every month up to six months)
研究者
Wilhelmina Annie Mensah
Ms
University of Ghana