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临床试验/NCT04837274
NCT04837274已完成不适用

Effects Of Tary Cherry Ingestion On Food-Induced Serum Uric Acid Elevation

Texas A&M University2 个研究点 分布在 1 个国家目标入组 24 人开始时间: 2020年4月10日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
24
试验地点
2
主要终点
Uric Acid Changes

研究概览

简要总结

The purpose of this study is to examine if tart cherry reduces food-induced elevations in serum uric acid.

详细描述

Gout is a painful form of arthritis that is caused by hyperuricemia (high uric acid levels) that form crystals in the joints. Ingestion of food and/or beverages containing high purine levels (e.g., beef, game meats, liver, shellfish, herring, mackerel, anchovies, sardines, mushrooms, dried beans and peas, sweetbreads, excessive alcohol, etc.) increase uric acid levels and thereby can complicate the management of uric acid levels in individuals with hyeruricemia and/or gout. Prior research has shown that ingestion of a chrysanthemum flower oil containing a high level of polyphenols significantly reduced the uricemic response to ingesting a meal high in purines. Additionally, black cherry and grape juice extracts are purported to have uric acid lowering properties. We have previoulsy reported that tart cherry powder, another naturally occuriring source of phlyphenols, lessens exercise-induced inflammation. This study will examine if tart cherry can also reduce the uricemic response to ingesting a high purine containing meal. If so, this may provide another dietary approach to help individuals manage their uric acid levels.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Treatment
盲法
Double (Participant, Investigator)

盲法说明

Double (Participant, Investigator)

入排标准

年龄范围
30 Years 至 60 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • They are healthy males or females ages 30 to 60 years with fasting serum uric acid (UA) levels between 5.5 and 8.0 mg/dl obtained during the familiarization/screening visit;
  • They have a willingness to provide voluntary, written, informed consent to participate in the study;

排除标准

  • They take prescription (Rx) medications (i.e., Uloric, Krystexxa, etc.) or dietary supplements known to have UA-reducing activity (i.e., black cherry, devil's claw, grape seed extracts, etc.);
  • They have regular diseases requiring regular prescription (Rx) medications (birth control is allowed);
  • They have abnormal/out of range values in laboratory tests determined at the familiarization/screening visit;
  • They have an allergy to tart cherry or immunoglobulin E;
  • They are pregnant, trying to become pregnant or breastfeeding;

结局指标

主要结局

Uric Acid Changes

时间窗: Measured at baseline (prior to supplementation (Pre)), and after 60, 120, 180 and 240 minutes

Serum Uric Acid changes to ingesting a high purine containing meal,

次要结局

  • Side Effects Assessment(Measured after 240 minutes (Post))

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Richard B. Kreider

Executive Director, Human Clinical Research Facility

Texas A&M University

研究点 (2)

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