Effects of Fructose Rich Diet Associated With Aerobic Training on Uric Acid Levels and Endothelial Function
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 21
- 试验地点
- 1
- 主要终点
- Flow Mediated Dilatation
研究概览
简要总结
Cardiometabolic diseases have been associated with high consumption of sweetened beverages. These products are responsible for the largest portion of the total consumption of fructose in the diet and it is suggested that excessive intake of this monosaccharide may contribute to the development of risk factors for these diseases due to differences in metabolism relative to glucose. However, there is a lack of data in the literature demonstrating the deleterious effects of excessive fructose consumption on vasodilation and whether aerobic training may be able to prevent or mitigate these damages in humans. Therefore, the aim of the study will be to verify the effect of 4 weeks of high fructose diet associated with aerobic training on uric acid levels and its influence on markers related to oxidative stress and vasodilatation. Twenty-one sedentary men and women, aged between 19 and 35 years, will be submitted to 4 weeks of intervention. In a randomized way, subjects will be divided into 3 groups: high fructose diet, high glucose diet and high fructose diet and exercise. Blood samples will be taken before, in the middle and after the intervention to verify the concentrations of uric acid, superoxide dismutase enzyme, thiobarbituric acid, nitrite / nitrate, lipid profile, glucose, insulin, C-reactive protein and endothelin-1. In addition, flow-mediated dilatation, insulin resistance index, pancreatic beta cell functional capacity index, oral glucose tolerance test, 24-hour blood pressure, heart rate variability and body composition will be analyzed. The comparisons will be performed through the Generalized Estimates of Equations, adopting the factors group and time. The Bonferroni post-hoc will be used to identify differences. The accepted level of significance will be 5%.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and women;
- •Not engaged in regular exercises;
- •Aged between 19 and 35 years;
- •Body mass index (BMI) of less than 30kg / m².
排除标准
- •Individuals with BMI below 18kg / m² and greater than 30kg / m²;
- •Dyslipidemic;
- •Diabetic;
- •Hypertensive;
- •Alcohol use;
- •Appetite suppressants use;
- •Medications use;
- •Supplements use;
- •Chronic disease that impedes the performance of physical exercise.
研究组 & 干预措施
Glucose-rich diet
Subjects will be submitted to a standard diet associated with a sweetened beverage (provided by the researchers) during 4 weeks. Without knowing the content (blind), they will receive glucose based beverage, prepared as a solution with 10% glucose, water and flavoring powder, totaling 1.0g / kg of body mass / day of glucose.
干预措施: Glucose (Dietary Supplement)
Fructose-rich diet
Subjects will be submitted to a standard diet associated with a sweetened beverage (provided by the researchers) during 4 weeks. Without knowing the content (blind), they will receive fructose based beverage, prepared as a solution with 10% fructose, water and flavoring powder, totaling 1.0g / kg of body mass / day of fructose.
干预措施: Fructose (Dietary Supplement)
Fructose-rich diet and exercise
The subjects will perform the same protocol described in the intervention Fructose-rich diet, except for the inclusion of the physical exercise. During the 4-week intervention, participants will perform three sessions a week of 60 minutes of aerobic exercise at 60% of VO2 peak on cycle ergometer.
干预措施: Fructose and exercise (Other)
结局指标
主要结局
Flow Mediated Dilatation
时间窗: 4 weeks
Concentration of Nitrite / Nitrate
时间窗: 4 weeks
Concentration of Uric Acid
时间窗: 4 weeks
次要结局
- Concentration of Total Cholesterol(4 weeks)
- Concentration of Substances Reactive to Thiobarbituric Acid(4 weeks)
- Concentration of Endothelin-1(4 weeks)
- Concentration of Insulin(4 weeks)
- Concentration of Superoxide Dismutase Enzyme(4 weeks)
- HOMA-IR(4 weeks)
- Insulin Sensitivity(4 weeks)
- Concentration of Triglycerides(4 weeks)
- Concentration of Low-Density Lipoprotein(4 weeks)
- HOMA-B(4 weeks)
- 24-hour Blood Pressure(4 weeks)
- Concentration of High-Density Lipoprotein(4 weeks)
- Concentration of Glucose(4 weeks)
- Concentration of C-Reactive Protein(4 weeks)
- Heart Rate Variability(4 weeks)
- Body Fat(4 weeks)
研究者
Alvaro Reischak-Oliveira
Principal Investigator
Federal University of Rio Grande do Sul