Unexpected Pharmacokinetics of Vancomycin in Patients With Severe Acute Pancreatitis Compared With Pneumonia
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- vancomycin serum trough concentrations in these patients just prior to the next vancomycin serum trough concentrations was measured
研究概览
简要总结
The purpose of this study was to evaluate the influence of severe acute pancreatitis on the serum level of vancomycin, a glycopeptide antibacterial agent.
详细描述
The purpose of this study was to evaluate the influence of severe acute pancreatitis on the serum level of vancomycin, a glycopeptide antibacterial agent.
After reviewing more than 6000 clinical charts of patients who received vancomycin therapy and whose serum vancomycin level was monitored between January 2010 and December 2013, we identified 212 patients who also had diagnosed as severe acute pancreatitis (SAP group), and 98 patients who also had diagnosed as pneumonia (pneumonia group) at that time. The fluorescence polarization immunoassay method was used to measure vancomycin serum trough concentrations in these patients 30 min before the next administration. Using these measurements, we calculated the pharmacokinetic parameters using the Bayesian estimator.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age 18-85years old
- •vancomycin use ≥ 3days
排除标准
- •age <18years old or >85 years old
- •vancomycin use < 3days
结局指标
主要结局
vancomycin serum trough concentrations in these patients just prior to the next vancomycin serum trough concentrations was measured
时间窗: patients will be followed for the duration of hospital stay, an expected average of 5 weeks
vancomycin serum trough concentrations was measured in patients just prior to the next dose at steady-state conditions (approximately after the fourth dose).
次要结局
- the pharmacokinetic parameters was calculated using the Bayesian estimator.(patients will be followed for the duration of hospital stay, an expected average of 5 weeks)