Sensory Symptoms as an Early Manifestation of Active Vitiligo: a Case-control Clinical and Molecular Study
试验速览
- 阶段
- 不适用
- 入组人数
- 90
- 主要终点
- Neuropeptide
研究概览
简要总结
This work aims to assess sensory symptoms in early active vitiligo patients (segmental, non-segmental, or mixed) and to measure 3 neuropeptides expression in their lesional skin [neuropeptide Y(NPY), calcitonin gene-related peptide (CGRP), and nerve growth factors (NGF)] to correlate neuropeptide levels, sensory symptoms, and functions, with criteria of disease activity and perceived stress scale.
详细描述
Study Design: Case-control study Population: 45 patients with active vitiligo and 45 patients with stable vitiligo
Inclusion criteria:
Age: 18 years old and older Sex: both sexes
Exclusion criteria:
Other hypopigmented diseases such as pityriasis alba, tinea versicolor, lichen sclerosis, post-inflammatory hyperpigmentation, and leprosy as excluded by lack of accentuation by wood's light examination. - Cases who received treatment (systemic or topical) in the last 3 months before sampling. - Neurological or other diseases that cause itching. - Medical history of DM, HTN, or other systemic diseases, history of associated autoimmune diseases.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Active and stable vitiligo
排除标准
- •Diabetic or other associated disease
结局指标
主要结局
Neuropeptide
时间窗: 3 months
laboratory test
次要结局
未报告次要终点