The Effects of 8-weeks of Probiotic and HMB Supplementation on Immune and Digestive Function in Special Operations Soldiers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 1
- 主要终点
- Maintenance of Immune function
研究概览
简要总结
The study will determine whether acute ingestion of a probiotic combined with beta-hydroxy-beta-methylbutyrate (HMB) can enhance immune and digestive function in soldiers during 8-weeks of advanced infantry training.
详细描述
Up to sixty soldiers from an elite infantry unit will perform a parallel design investigation. Soldiers will be randomly assigned to one of four groups. Group 1 will consume the probiotic plus HMB, group 2 will consume HMB only, group 3 will consume only the probiotic, and group 4 will consume only placebo. All four groups will be garrisoned together, eat the same meals, and perform the same activity. All groups will be tested before as well as after an 8-week advanced infantry training program. During each testing session resting blood samples will be obtained to assess cytokine, inflammatory, and muscle damage markers. Additionally, questionnaires will be used to determine digestive health. Anthropometric, performance, and muscle volume measures will also be assessed prior to and immediately following the supplementation and training protocol.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 30 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18 years of age
- •Member of the same unit of the IDF
排除标准
- •Current use of dietary supplements
- •Current chronic use of medications
研究组 & 干预措施
Placebo
Placebo capsules similar to the experimental treatments.
干预措施: Placebo (Dietary Supplement)
HMB
HMB capsules providing 3 g of calcium HMB per day.
干预措施: HMB (Dietary Supplement)
HMB + BC30
Capsules providing 3 g calcium HMB per day plus Bacillus Coagulans GBI-30, 6086 (BC30) mixed in water.
干预措施: HMB (Dietary Supplement)
HMB + BC30
Capsules providing 3 g calcium HMB per day plus Bacillus Coagulans GBI-30, 6086 (BC30) mixed in water.
干预措施: BC30 (Dietary Supplement)
结局指标
主要结局
Maintenance of Immune function
时间窗: 8 weeks
Immune function assessed by blood biochemical analysis (ELISA).
次要结局
- Maintenance of Digestive Function(8 Weeks)
- Maintenance of Muscle Volume(8 Weeks)
