Frequency of Diagnostic Symptomatic Pulmonary Embolism's in Patients Hospitalized for Clinical Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 750
- 试验地点
- 13
- 主要终点
- Frequency of pulmonary embolism in patients hospitalized for a clinical exacerbation of COPD.
研究概览
简要总结
A standardized diagnostic strategy of pulmonary embolism will be applied to eligible patients, incorporating a clinical probability score (revised Geneva score), plasma D-dimer assay and if necessary, a multidetector-row CT angiography thoracic and venous ultrasound of the lower limbs. All the patient with a pulmonary embolism diagnosed or not, will be followed for 3 months.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients hospitalized for a COPD exacerbation
- •COPD previously diagnosed
排除标准
- •Allergy to iodinated contrast
- •Creatinine clearance < 30 mL / min
- •Patient hospitalized for exacerbation of COPD for more than 48 hours
- •Pneumothorax
- •Exams impossible to be performed
- •Pregnancy
- •Life expectancy < 3 months
- •Patients already receiving anticoagulant therapy for another reason (mechanical valve, cardiac arrhythmia).
研究组 & 干预措施
PEP
No drug and no placebo were used in this study. For all the patients who participated at the study PEP, only following exams must be performed: a clinical probability score (revised Geneva score), plasma D-dimer assay and if necessary, a chest multidetector-row CT angiography and venous ultrasound of the lower limbs
干预措施: PEP (Other)
结局指标
主要结局
Frequency of pulmonary embolism in patients hospitalized for a clinical exacerbation of COPD.
时间窗: 27 months
次要结局
- The rate of pulmonary embolism diagnosed during the 3 month follow-up in patients whom pulmonary embolism was initially excluded when they've been included in the study(27 months)