Enhanced Prediction Model for Major Adverse Events Following Acute Myocardial Infarction
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 1,544
- 试验地点
- 1
- 主要终点
- Recurrent myocardial infarction or cardiac death
研究概览
简要总结
Acute myocardial infarction (AMI) remains a leading cause of mortality worldwide. Although early revascularization has markedly improved short-term outcomes, the incidence of major adverse cardiovascular events after the index event remains unacceptably high, posing a formidable clinical challenge. Contemporary risk-stratification instruments rely predominantly on a restricted set of conventional clinical variables and therefore fail to capture the full spectrum of individual pathophysiological complexity. To overcome these limitations, the present investigation aims to develop a post-AMI prognostic model that integrates comprehensive multimodal data.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years old
- •Presented with myocardial infarction, including NSTEMI and STEMI
- •Undergoing successful percutaneous coronary intervention.
排除标准
- •Subjects who decline protocol-mandated follow-up or withhold informed consent.
- •Individuals whose expected survival is < 1 year.
结局指标
主要结局
Recurrent myocardial infarction or cardiac death
时间窗: At 24-month Follow-up
Patients received recurrent myocardial infarction or cardiac death
Diagnostic performance
时间窗: At 24-month follow-up
Diagnostic performance of the AI-driven multimodal predictive model: area under the receiver-operating characteristic curve (AUC), sensitivity, specificity, overall accuracy, positive predictive value (PPV), and negative predictive value (NPV).
MACE at 24 months
时间窗: At 24-month follow-up
Major adverse cardiovascular events, defined as a compisite of cardiac death, myocardial infarction, target vessel revascularization.
次要结局
- MACE at 60 months(At 60-month follow-up)