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临床试验/NCT04445350
NCT04445350Unknown不适用

Motor Learning in Knee Osteoarthritis Therapy - A New Rehabilitation Approach

St. Pölten University of Applied Sciences2 个研究点 分布在 1 个国家目标入组 50 人开始时间: 2018年11月1日最近更新:
适应症

试验速览

阶段
不适用
发起方
入组人数
50
试验地点
2
主要终点
Knee Adduction Moment (change over a period of 6 month with 3 measurement dates)

研究概览

简要总结

Non-surgical treatment options, like exercise therapy, show excellent short-term effects regarding pain reduction and improvement of knee function. However, mid- and long-term effects are missing so far. This might indicate that long-lasting changes in motor-skill performance (Motor Learning) have not occurred. Motor learning is associated with permanent changes in the capability for skilled movement behavior avoiding unfavorable joint loads and inappropriate muscle activation patterns, leading to compensatory movement strategies. One-sided and high repetitive loads in the knee joint could be one reason for the progression of knee osteoarthritis. Physiotherapeutic strategies should therefore be able to stimulate motor learning processes. In physiotherapy, motor learning can be optimized by using instructions and feedback, targeting an external focus of attention, when learning specific movement patterns. This study investigates the effects of a 12 week exercise therapy program, using an external focus of attention, on functional and biomechanical parameters in patients with knee osteoarthritis. To measure possible changes, functional measurements are taking place at baseline, after 6, 12 and 24 weeks. The biomechanical measurements (3D gait analysis) are taking place at baseline, after 12 and 24 weeks.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Double (Participant, Outcomes Assessor)

入排标准

年龄范围
45 Years 至 60 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Kellgren-Lawrence-Score 1-3
  • BMI < 33
  • Free range of motion in the knee joint

排除标准

  • Activated knee osteoarthritis
  • Lower extremity surgery in the past 6 weeks
  • Intake or injection of corticosteroids in the past 3 month
  • Long-term medication non-steroidal anti-inflammatory drugs
  • Neurological diseases
  • Drug or alcohol abuse

结局指标

主要结局

Knee Adduction Moment (change over a period of 6 month with 3 measurement dates)

时间窗: Baseline, 12 weeks, 24 weeks

3D gait analysis during walking

Knee Osteoarthritis Outcome Score (change over a period of 6 month with 4 measurement dates)

时间窗: Baseline, 6 weeks, 12 weeks, 24 weeks

Questionnaire; Minimum value: 0 (highest limitation), Maximum: 100 (no limitation)

Star Excursion Balance Test (change over a period of 6 month with 4 measurement dates)

时间窗: Baseline, 6 weeks, 12 weeks, 24 weeks

An established test to determine movement control and balance ability. The test person stands on one leg and will is asked to stretch the non supporting leg as far as possible in the directions presented.

Six minute walking test (change over a period of 6 month with 4 measurement dates)

时间窗: Baseline, 6 weeks, 12 weeks, 24 weeks

The six minute walking test is a reliable measuring tool to examine the distance a person can walk in a given time period.

Isometric strength tests (change over a period of 6 month with 4 measurement dates)

时间窗: Baseline, 6 weeks, 12 weeks, 24 weeks

Measures the isometric force of the knee extensors, knee flexors, hip abductors, hip extensors and hip external rotators with a portable dynamometer

次要结局

未报告次要终点

研究者

发起方
St. Pölten University of Applied Sciences
申办方类型
Other
责任方
Principal Investigator
主要研究者

Wondrasch

FH-Professor Barbara Wondrasch, PhD

St. Pölten University of Applied Sciences

研究点 (2)

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