A prospective study of utility of [18F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the initial staging and response assessment of locally advanced breast cancer patients receiving neoadjuvant chemotherapy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- 1.To evaluate the utility of FDG PET/CT in initial staging of locally advanced breast cancer.
研究概览
简要总结
Breast cancer is the most common cancer among urban women and second among rural women in India. Majority of the women present at an advanced stage. Patients presenting clinically with LABC are evaluated with traditional imaging methods to look for metastatic disease. One drawback of the conventional imaging modalities is the extent to which they may underestimate the metastatic disease. PET/CT combines the metabolic imaging with the anatomical imaging and can be more valuable is detecting metastatic disease than the conventional methods.
The standard treatment of locally advanced breast cancer is neoadjuvant chemotherapy followed by locoregional treatment. Tools to assess the response of neoadjuvant chemotherapy include clinical assessment, CT, MRI, and mammogram. All of these modalities are far from accurate. Again PET/CT by combining metabolic imaging with anatomical information can prove more useful. hence the present study looks to predict the utility of PET/CT in detecting the site of metastasis and assessing the response to chemotherapy.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18.00 Year(s) 至 90.00 Year(s)（—）
- 性别
- Female
入选标准
- •biopsy proven locally advanced breast cancer women.
排除标准
- •Patients with early breast cancer or found to have metastatic disease on conventional imaging will be excluded from the study.
- •Patients who have already received treatment elsewhere will be excluded.
- •Male patients with breast cancer will not be included.
结局指标
主要结局
1.To evaluate the utility of FDG PET/CT in initial staging of locally advanced breast cancer.
时间窗: February 2015
4.Usefulness of PET/CTin selection of patients for breast conservation surgery vs mastectomy after NACT
时间窗: February 2015
2.To compare FDG PET/CT with conventional methods in staging of locally advanced breast cancer
时间窗: February 2015
3.To evaluate the role of FDG PET/CT in predicting pathological response to neoadjuvant chemotherapy in comparison to other methods
时间窗: February 2015
次要结局
- Usefulness of PET/CTin selection of patients for breast conservation surgery vs mastectomy after NACT