Role of A. Lumbricoides in the Development of Pulmonary Aspergillosis in Chronic Obstructive Pulmonary Disease Patients
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 200
- 试验地点
- 2
- 主要终点
- Serum tumor necrosis factor-a levels in COPD patients and controls
研究概览
简要总结
The prevalence of ascariasis in COPD patients with and without concomitant pulmonary aspergillosis and in controls will be determined. To assess the influence of ascaridosis on the development of pulmonary aspergillosis in COPD patients cytokine status of patients will be studied.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 30 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •COPD patients
- •COPD patients with aspergillosis
- •COPD patients with ascariasis
- •COPD patients with mix-infection
- •Healthy individuals (controls)
排除标准
- •COPD patients with other autoimmune diseases
- •COPD patients with oncological diseases
- •COPD patients with other co-infections
研究组 & 干预措施
COPD patients with chronic pulmonary aspergillosis and ascariasis
干预措施: Interleukin-4 (Diagnostic Test)
healthy control
干预措施: Interleukin-4 (Diagnostic Test)
COPD patients with chronic pulmonary aspergillosis
干预措施: Interleukin-4 (Diagnostic Test)
COPD patients with ascariasis
干预措施: Interleukin-4 (Diagnostic Test)
COPD patients without any comorbidities
干预措施: Interleukin-4 (Diagnostic Test)
结局指标
主要结局
Serum tumor necrosis factor-a levels in COPD patients and controls
时间窗: up to 12 months
Serum tumor necrosis factor-a (pg/mL) levels will be measured in COPD patients without concomitant infection, COPD patients with pulmonary aspergillosis, COPD patients with ascariasis, COPD patients with ascariasis and pulmonary aspergillosis, and healthy individuals.
Serum interferon-gamma levels in COPD patients and controls
时间窗: up to 12 months
Serum interferon-gamma (pg/mL) levels will be measured in COPD patients without concomitant infection, COPD patients with pulmonary aspergillosis, COPD patients with ascariasis, COPD patients with ascariasis and pulmonary aspergillosis, and healthy individuals.
Serum interleukin-1B levels in COPD patients and controls
时间窗: up to 12 months
Serum interleukin-1B (pg/mL) levels will be measured in COPD patients without concomitant infection, COPD patients with pulmonary aspergillosis, COPD patients with ascariasis, COPD patients with ascariasis and pulmonary aspergillosis, and healthy individuals.
Serum interleukin-4 levels in COPD patients and controls
时间窗: up to 12 months
Serum interleukin-4 (pg/mL) levels will be measured in COPD patients without concomitant infection, COPD patients with pulmonary aspergillosis, COPD patients with ascariasis, COPD patients with ascariasis and pulmonary aspergillosis, and healthy individuals.
Correlation between cytokine status with chronic pulmonary aspergilosis insidence rate in COPD patients with and without ascariasis
时间窗: up to 12 months
The correlation between serum interleukin-1B, interleukin-4, interleukin-6, tumor necrosis factor-a and interferon-y levels with chronic pulmonary aspergilosis insidence rate in COPD patients with and without ascariasis will be assessed.
Serum interleukin-6 levels in COPD patients and controls
时间窗: up to 12 months
Serum interleukin-6 (pg/mL) levels will be measured in COPD patients without concomitant infection, COPD patients with pulmonary aspergillosis, COPD patients with ascariasis, COPD patients with ascariasis and pulmonary aspergillosis, and healthy individuals.
次要结局
- Rate of ascariasis infestation among COPD patients and controls(up to 12 months)
研究者
Svetlana Osipova, MD, PhD, DS
Head of Department of Immunology of Parasitic and Fungal Diseases
Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan