Eradication of carbapenem-resistant Klebsiella pneumoniae gastrointestinal colonization and prevention of secondary bloodstream infections with oral colistin

Sultan Qaboos University0 个研究点目标入组 92 人开始时间: 2023年1月12日最近更新: 2023年10月9日

试验速览

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•Current inclusion criteria as of 09/05/2023:
•1. Adult: Aged >18 years
•2. Location: ICU, HD, Hematology
•3. Able to provide informed consent
•4. Expected to stay for 14 days in hospital
•5. Undergone a screening rectal swab for CRKP within 72 h of admission
•Previous inclusion criteria:
•1. Aged =18 years
•2. Admitted to intensive care, high dependency, and hematology wards at SQUH, Oman during the study period
•3. Positive screening rectal swab for CRKP [colistin susceptible]
•4. Able to provide informed consent

•Current exclusion criteria as of 09/05/2023:
•1. Not meeting inclusion criteria
•2. Rectal swab is negative for CRKP
•3. CRKP is colistin-resistant [MIC >2 mg/L)
•4. Pregnant or nursing women
•5. Known hypersensitivity to colistin/placebo
•6. NPO [nil by mouth]
•7. On colistin OR ceftazidime-avibactam/aztreonam at time of enrollment or up to 7 days before enrollment
•Previous exclusion criteria:
•1. Age <18 years
•2. Pregnant or nursing women
•3. Known hypersensitivity
•4. Gastrointestinal colonization with colistin-resistant Klebsiella pneumonia
•5. Enrollment in the present study for a previous episode

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