Effect of Different Posture on Optic Nerve Sheath Diameter During Thoracic Epidural Catheterization
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 44
- 试验地点
- 2
- 主要终点
- optic nerve sheath diameter change among 4 time period
研究概览
简要总结
Intracranial pressure is measured indirectly using optic nerve sheath diameter with ultrasound. It is reported that epidural pressure varies according to different posture ( lateral decubitus vs. sitting position).
This study is designed to measure the optic nerve sheath diameter in lateral decubitus and sitting position, respectively.
详细描述
According to previous study, injection of different volume of local anesthetics (1.0 ml/kg vs. 1.5 ml/kg) during caudal anesthesia, high volume of local anesthetics resulted in significant increase of intracranial pressure (ICP). Increase of ICP can reduce regional cerebral flow and oxygen saturation causing the safety of patients. In addition, increase of ICP can result in headache, syncope, and transient loss of visual acuity. Although it is very invasive method, ICP can be measured directly at the brain parenchyme. Among methods to measure the ICP indirectly, measurement of optic nerve sheath diameter using ultrasound is known to reflect the degree of ICP. It is reported that optic nerve sheath diameter increases when higher volume of medication is injected during epidural anesthesia. Previous reports showed that epidural pressure varies according to different posture. When epidural pressure was measured in patients of spinal stenosis, lumbar flexion showed lower epidural pressure than epidural pressure of lumbar extension. In addition, when epidural pressure was measured in the sitting position, it showed lower pressure than pressure of lateral decubitus.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 80 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •lung cancer
- •liver cancer
- •stomach cancer
- •pancreas cancer
排除标准
- •coagulopathy
- •infection
- •previous spine fusion at thoracic level
- •previous brain surgery
结局指标
主要结局
optic nerve sheath diameter change among 4 time period
时间窗: Baseline, 10 minutes, 20 minutes, 40 minutes after the completion of the intervention
optic nerve sheath diameter change among 4 time period using ultrasound
次要结局
未报告次要终点
研究者
Ji Hee Hong
Professor
Keimyung University Dongsan Medical Center
