Study of the Role of Menstrual Blood-derived Stem Cells and the Immune Environment in Endometriosis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 40
- 试验地点
- 2
研究概览
简要总结
Endometriosis is a chronic inflammatory condition characterized by the presence of endometrium-like tissue outside the uterine cavity. It is estimated to affect approximately 10% of women of reproductive age and it is associated with chronic pelvic pain and infertility, among other symptoms.
Endometriosis involves complex changes in the body's cells and immune response. For this reason, the goal of this observational study is to characterize the functional, molecular, and immunological alterations in menstrual blood-derived stem cells (MenSCs) and differentiated decidual stromal cells in women with endometriosis; to validate these findings in endometrial tissue and endometriomas; and to establish their correlation with clinical parameters, with the aim of identifying key pathogenic mechanisms and potential therapeutic targets.
The main questions it aims to answer are:
- Are there functional and molecular changes in MenSCs from patients with endometriosis compared to healthy volunteers?
- Are there any variations in the immune properties of MenSCs throughout the menstrual bleeding period in patients with endometriosis compared to healthy volunteers?
- Are these changes also present in endometrial tissue and endometrioma samples?
- Can these changes be correlated with clinical parameters in patients with endometriosis?
- Can MenSCs serve as a potential therapeutic target for endometriosis?
Some participants will be asked to provide menstrual blood on a single day, while others will provide samples during the first five days of menstruation. Additionally, all participants will answer questionnaires about their diet, physical activity, stress, and pain levels. Therefore, the study does not involve the evaluation of a specific intervention on the participants.
The results will enable the identification of key altered mechanisms and potential therapeutic targets, thereby contributing to the development of more effective strategies for the diagnosis and treatment of the disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •18-45 years.
- •Endometriosis group: Women with clinical and/or ecographical diagnostic of endometriosis.
- •Control group: Women with the endometriosis diagnosis.
排除标准
- •<18 years or >45 years.
- •Pregnancy or lactation.
- •Diagnosis of prior chronic pelvic inflammatory or autoimmune disease.
- •History of active gynecological cancer.
- •Positive for human immunodeficiency virus (HIV) or human papillomavirus (HPV).
- •Hormonal therapy use in the previous 3 months.
- •Use of immunosuppressants or corticosteroids in the previous 3 months.
- •Systemic antibiotics use in the previous 3 months.
- •Insufficient menstrual flow to allow the MenSCs isolation.
研究者
Francisco Algaba Chueca
Senior Lecturer
University Rovira i Virgili