NL-OMON47772已完成不适用
Evaluating retinal blood flow autoregulation by means of Optical Coherence Tomography Angiography (OCT-A)<br> - Autoregulation of retinal blood flow<br>
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 125
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 64（—）
入选标准
- •subjects between 50 and 65 years;- Group #1: Symptomatic low blood pressure individuals
- •Defined as having at least one of: systolic blood pressure below 98 mmHg or diastolic blood pressure below 58 mmHg (without the use of any antihypertensive treatment), and at least one of:
- •a) migraine:
- •Migraine is defined as already diagnosed, or a score of 4 or 5 in the corresponding section of the questionnaire, according to the Migraine Screening Questionnaire.
- •b) orthostatic hypotension:
- •Orthostatic hypotension is defined as already diagnosed, or a sustained reduction of systolic blood pressure (SBP) of at least 20 mmHg or diastolic blood pressure (DBP) of 10 mmHg within 3 minutes of standing.
- •c) cold intolerance:
- •Cold intolerance is defined as a score of 30 or more in the corresponding section of the questionnaire.;- Group #2: Asymptomatic low blood pressure individuals
- •Defined as having at least one of: systolic blood pressure below 98 mmHg or diastolic blood pressure below 58 mmHg (without the use of any antihypertensive treatment), and none of the symptoms described in Group #1.;- Group #3: Asymptomatic normal blood pressure individuals
- •Defined as having systolic blood pressure between 113 and 143 mmHg, and diastolic blood pressure between 67 and 85 mmHg (without the use of any antihypertensive treatment), and none of the symptoms described in Group #1.;- Group #4: Asymptomatic untreated high blood pressure individuals
- •Defined as having at least one of: systolic blood pressure above 158 mmHg or diastolic blood pressure above 94 mmHg, not using any antihypertensive treatment, and having none of the symptoms described in Group #1.;- Group #5: Treated high blood pressure individuals
- •Defined as having systolic blood pressure below 135 mmHg and diastolic blood pressure below 79 mmHg, together with a medical history of hypertension and the use of any antihypertensive medication for at least the past 1 year.
排除标准
- •visual acuity less than 0.8
- •intra-ocular pressure more than 21 mmHg
- •any visual field defect
- •sphere of more than (+/-)3D or cylinder of more than (+/-)2D
- •positive family history (father, mother, brother or sister) of glaucoma
- •OCT-A image quality of 6 or less
- •pathological fundus photographs
- •diagnosed diabetes mellitus of any type
- •medical history of cerebrovascular disease, heart disease or severe anemia
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