Impact of IPV on mucosal immunity: A randomized controlled trial comparing nasopharyngeal and intestinal poliovirus shedding after bOPV challenge in IPV recipients with those not receiving IPV

World Health Organization0 个研究点目标入组 400 人开始时间: 2023年12月15日最近更新: 2024年1月8日

试验速览

暂无简介。

•1.Healthy infants born June-August 2023 (i.e, 6-8 months of age at time of enrolment in February 2024) residing in Camaguey province of Cuba
•2.Over the 3rd percentile for height and weight
•3.Resident of the study locality for more than or at least 5 months, with no plans to move
•4.Previously received one dose of fIPV in primary series at 4 months of age
•5.Parent/guardian consent for participation in the study and for samples collection

•1.Infant not fulfilling inclusion criteria
•2.Contraindication for venepuncture
•3.Having received bOPV or 2nd fIPV dose before enrolment
•4.Acutely sick child or child requiring hospitalization. These children will be referred to the nearest medical facility equipped to handle the case at their own expense.
•5.Diagnosis or suspicion in the subject or an immediate family member of congenital medical conditions (e.g., Down Syndrome); primary immunodeficiency disorder; chronic medical illness (e.g., renal, cardiac)
•6.Infants of mothers below the legal age (<18 years) or with mental incapacity will not be eligible to participate.

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