Impact of Continuous Renal Replacement Therapy on Renal Oxygenation, Blood Flow and Function
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Renal blood flow and CRRT
研究概览
简要总结
Approximately 50% of patients in the intensive care unit (ICU) develop acute kidney injury (AKI) and more than 10% need dialysis. There is no treatment for AKI. Care is aiming for optimization of circulation and blood flow to the kidneys and avoiding nephrotoxic agents.
There is conflicting data concerning whether early or late dialysis is harmful for the kidneys. No one has examined the physiological changes in the kidney when starting dialysis and which blood pressure that leads to most optimal physiological conditions for the kidneys during dialysis. In this descriptive study of 20 ICU patients suffering from AKI we aim to investigate renal physiology when starting continuous renal replacement therapy (CRRT) and also at different target blood pressures using retrograde renal vein thermodilution technique. In parallel we will also investigate and validate this invasive method with contrast enhanced ultrasound of the kidneys.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •AKI, according to KDIGO, stage 2 or 3 but with preserved urine production. Treated in the ICU at Sahlgrenska University Hospital Written, signed informed consent Male and female subjects ≥18 years
排除标准
- •Emergency need for dialysis Allergy to contrast media (used for CEUS)
结局指标
主要结局
Renal blood flow and CRRT
时间窗: 6 hours
Changes in renal blood flow when CRRT is started? How will renal blood flow and oxygenation change at different blood pressure targets?
Renal blood flow and blood pressure
时间窗: 6 hours
Renal blood flow changes at different mean arterial blood pressure targets during CRRT?
Renal oxygenation during CRRT
时间窗: 6 hours
Renal oxygenation before CRRT and during CRRT
Glomerular filtration rate (GFR) and CRRT
时间窗: 6 hours
Changes in GFR when CRRT is started?
Glomerular filtration rate (GFR) and blood pressure
时间窗: 6 hours
GFR changes at different mean arterial blood pressure targets during CRRT?
Renal oxygenation and blood pressure
时间窗: 6 hours
Renal oxygenation changes at different mean arterial blood pressure targets during CRRT?
次要结局
- Contrast enhanced renal ultrasound (CEUS)(2 hours)
- atrial natriuretic peptide (ANP)(6 hours)
研究者
Kristina Svennerholm
Principal investigator, MD, PhD
Sahlgrenska University Hospital