Cohort of Patients With Covid19: Constitution of Blood Samples Collections With Clinical Characterization
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 500
- 试验地点
- 2
- 主要终点
- Phenotype/genotype correlation research modulating the severity of Covid-19 disease
研究概览
简要总结
Biological collection (blood sample) associated with clinical data from Covid-19 patients
详细描述
SARS-Cov2 is an emerging respiratory virus in the coronavirus family, responsible of the pandemic since November 2019. France, which has more than 17,000 deaths from the virus, is one of the main outbreaks. As of 16 April 2020, more than 76,000 individuals in France have been hospitalized, corresponding to 69% of confirmed cases (https://www.santepubliquefrance.fr).
Most affected patients have more or less marked clinical signs associating fever, cough, dyspnea, myalgia, anosmia, ageusia, digestive disorders. In some cases, the progression is worse with lung disease of varying severity. Indications for hospitalization are essentially the severe forms of Covid-19 disease, characterized by hypoxemic lung disease.
Risk factors for developing severe Covid-19 disease have been identified already: age, co-morbidity such as diabetes, obesity-overweight or cardiovascular diseases. It is assumed that other host-related factors, including genetics, may contribute to the existence of this phenotypic heterogeneity. At present, these factors are not known.
The objective of this research is to constitute a DNA collection from patients with Covid-19, in order to be able to search for genetic factors modulating the clinical phenotype.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of COVID-19 confirmed on RT-PCR test or chest scanner
- •Membership in the general social security system
- •Inform consent signed by the patient or by legal representatives for minors
排除标准
- •Refusal of the patient or one of the legal representatives
结局指标
主要结局
Phenotype/genotype correlation research modulating the severity of Covid-19 disease
时间窗: Anytime in the period of 10 years
Clinical aggravation markers (admission in intensive care)
次要结局
- Phenotype/transcriptomic correlation research modulating the severity of Covid-19 disease(Anytime in the period of 10 years)
- Development of predictive imaging scores in the severity of Covid-19 disease(Anytime in the period of 10 years)
- Development of clinical-biological scores in the severity of Covid-19 disease(Anytime in the period of 10 years)
- Phenotype/biomarker correlation research modulating the severity of Covid-19 disease(Anytime in the period of 10 years)
- Identification of transcriptomic markers for treatment response(Anytime in the period of 10 years)
- Identification of pathophysiological pathways to susceptibility to Covid-19 disease(Anytime in the period of 10 years)
- Identification of genetic markers for treatment response(Anytime in the period of 10 years)
- Identification of proteomic for treatment response(Anytime in the period of 10 years)