Effects of Legumes Consumption on Weight Reduction
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 400
- 主要终点
- Changes of urinary 8-epi-PGF2α
研究概览
简要总结
This is a 12-week, randomized nutritional intervention study to determine the effect of legumes consumption on body weight in obese subjects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male and female volunteers between the ages of 20 to 70 years
- •Body mass index (BMI) of 25 kg/m2 or higher (based on Asia-Pacific guideline)
- •Volunteers who have agreed to participate in the study and provided a written content by him/herself
排除标准
- •Those with type 2 diabetes, cardiovascular disease, psychiatric problems, thyroid disorders, liver or kidney disease
- •Those under the use of any medications (antihypertensive, lipid-lowering, antiplatelet, antidiabetic, etc.).
结局指标
主要结局
Changes of urinary 8-epi-PGF2α
时间窗: 12 weeks
Changes of urinary 8-epi-PGF2α in pg/mg creatinine was assessed before and after the intervention.
Changes of Insulin Resistance (IR)
时间窗: 12 weeks
Changes of fasting serum glucose in mmol/L was assessed before and after the intervention. Changes of fasting insulin in μIU/mL was assessed before and after the intervention. Fasting insulin and fasting glucose were combined to report IR using the following equation: homeostasis model assessment (HOMA)-IR=\[fasting insulin (μIU/mL)×fasting glucose (mmol/L)\] /22.5.
Changes of serum high C-reactive
时间窗: 12 weeks
Changes of serum high C-reactive in mg/L was assessed before and after the intervention.
Changes of adiponectin
时间窗: 12 weeks
Changes of adiponectin in ng/mL was assessed before and after the intervention.
Changes of BMI
时间窗: 12 weeks
Changes of weight in kilograms was assessed before and after the intervention. Changes of height in meters was assessed before and after the intervention. Weight and height were combined to report BMI in kg/m\^2.
Changes of lipid profiles
时间窗: 12 weeks
Triglyceride in mg/dL was assessed before and after the intervention. Total-cholesterol in mg/dL was assessed before and after the intervention. HDL-cholesterol in mg/dL was assessed before and after the intervention. LDL-cholesterol was indirectly estimated using the friedewald formula: LDL-cholesterol= total-cholesterol-\[HDL-cholesterol+(triglycerides/5)\].
次要结局
未报告次要终点
研究者
Jong Ho Lee
Professor, Principal Investigator
Yonsei University