Sensitive Imaging in Ankylosing Spondylitis - SIAS

eids Universitair Medisch Centrum0 个研究点目标入组 40 人开始时间: 待定最近更新: 2024年8月12日

适应症

试验速览

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•a) Male and female patients of at least 18 years having Ankylosing Spondylitis (AS) fulfilling the Modified New York criteria, in which a patient has *definite* AS if the radiological criterion is associated with at least one clinical criterion: ;Clinical criterions:
•* low back pain and stiffness for more than 3 months that improves with exercise, but is not relieved by rest.
•* limitation of motion of the lumbar spine in the sagittal and frontal planes.
•* limitation of chest expansion relative to normal values correlated for age and sex.;Radiological criterion (sacroiliitis grade >= 2 bilaterally or grade 3-4 unilaterally)
•* grade 0 = no sacroiliitis
•* grade 1 = blurring of the joint margins (*suspicious*)
•* grade 2 = sclerosis, erosions, no changes in joint space
•* grade 3 = erosions, changes in joint space, partial ankylosis
•* grade 4 = complete ankylosis;b) Patients should have at least one syndesmophyte in either the cervical or lumbar spine radiograph at baseline conventional radiography. The maximum number of VUs is 9 (out of 12). ;c) The patient should have given written informed consent.

•* > 9 by syndesmophytes affected vertebral units.;* A history of alcoholism, drug abuse, psychological or other emotional problems, severe comorbidity likely to invalidate informed consent or limit the ability of the subject to comply with the protocol requirements.;* Routine MRI-contraindications (e.g. instable metal implants, pacemaker/ICD, vascular clips, hearing aids and claustrophobia).;* Pregnancy.

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