The Effect of Vaginal Progestrone on Fetal and Maternal Doppler Indices
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 80
- 试验地点
- 2
- 主要终点
- change of ultrasound doppler indices.
研究概览
简要总结
The aim of our study is to assess the effect of vaginal progestrone on fetal and maternal doppler indices
详细描述
A complete Doppler flow assessment of the maternal and fetal circulation was conducted by an independent investigator blinded to the treatment, before and 48 hours after the first administration of 400mg of vaginal progesterone, Voluson E8 (GE Healthcare, Zipf, Austria) ultrasound machine,equipped with a 3.5- MHz curvilinear abdominal transducer with color imaging capabilities, was used in all cases.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Gestational age: 18-33 weeks
- •Willing and able to give informed consent
- •History of preterm labor (<34 weeks)
- •At risk for preterm labor ( increased amniotic fluid volume)
- •Short cervical length (<25mm) as incidental finding
- •Presenting with actual cervical changes ( dilatation and\or effacement) in current pregnancy
排除标准
- •Contraindication to progesterone use
- •Diabetic patients, have glucose intolerance
- •Multiple pregnancies
研究组 & 干预措施
vaginal progestrone group
cohort of patients who received 400mg vaginal progestrone .
干预措施: A complete Doppler flow assessment of the maternal and fetal circulation (Diagnostic Test)
结局指标
主要结局
change of ultrasound doppler indices.
时间窗: before and 48 hours after progestrone admistration
A complete Doppler flow assessment of the maternaland fetal circulation was conducted by an independent investigator blinded to the treatment, before and 48 hours after the first administration of progesterone, Voluson E8 (GE Healthcare, Zipf, Austria) ultrasoundmachine,equippedwitha3.5-MHzcurvilinearabdominaltransducer with color imaging capabilities, was used in all cases.
次要结局
未报告次要终点
研究者
sarah mohamed hassan
lecturer of obstetrics and gynecology Cairo university
Kasr El Aini Hospital