Effects of Early Antibiotic Exposure on Gut Microbiota and Motility Establishment in Newborns: a Prospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- gut microbiota
研究概览
简要总结
This prospective cohort study aims to investigate the impact of early antibiotic exposure on the establishment of gut microbiota and motility in newborns, particularly preterm infants. The study will explore the correlation between antibiotic exposure, gut microbiota colonization, and 5-hydroxytryptamine (5-HT) levels, which are critical for gastrointestinal motility. The findings may provide insights into optimizing antibiotic use and improving gastrointestinal health in neonates.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 24 Weeks 至 36 Weeks（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Newborns admitted within 72 hours of birth
- •Gestational age 24-36 weeks (preterm) and term infants
- •Informed consent obtained from parents or guardian
排除标准
- •Congenital gastrointestinal malformations (e.g., intestinal atresia, Hirschsprung's disease)
- •Severe systemic or organ-specific diseases
- •Expected mortality due to severe illness
结局指标
主要结局
gut microbiota
时间窗: Enrollment Period: This is the time during which participants will be recruited and enrolled into the study. You have specified that enrollment will occur from November 2024 to November 2027. Intervention Period: Since this is an observational study, the
Impact of antibiotic exposure on gut microbiota colonization assessed by 16S rRNA sequencing.
次要结局
未报告次要终点