Elucidating the effects of nebulized sodium nitrite and argon on blood pressure and cerebrovascular haemodynamics in healthy adults and hypertensive patients

niversity of Auckland0 个研究点目标入组 80 人开始时间: 2022年10月14日最近更新: 2024年4月15日

适应症

试验速览

暂无简介。

•Patients with essential hypertension (At least Stage 2 hypertension; untreated office systolic blood pressure (SBP) greater than or equal to 140 mmHg or diastolic blood pressure (DBP_ greater than or equal to 90 mmHg);
•Patients with chronic atrial fibrillation, as established on ECG or Holter monitoring
•Normotensive controls (office SBP less than or equal to 120 mmHg and DBP less than or equal to 80 mmHg);
•Aged over 18 years;
•Body mass index less than 35 kg/m2.

•Hemodynamically significant valvular heart disease (excluding atrial fibrillation e.g., stenosis, mechanical valve replacement)
•Severe left ventricular systolic dysfunction
•Recent acute coronary syndrome (<12 months) (e.g., myocardiac infarction, angioplasty, unstable angina)
•Previous coronary artery bypass surgery
•Secondary causes of hypertension (e.g., phaeochromocytoma)
•Recent stroke/transient ischaemic attack (<12 months)
•Current smoker
•Body mass index <18 kg/m2.
•Current pregnancy
•Current user of recreational drugs
•Current abuser of alcohol
•Inability to fully or appropriately provide consent (e.g., language issue, reading capability)
•Underlying medical conditions, which in the opinion of the Investigator place the participant at unacceptably high risk for participating in the study.
•Chronic and systemic illness including:
•Severe respiratory disease (e.g., chronic obstructive pulmonary disease);
•Severe, uncontrolled type II diabetes;
•Current treatment for cancer or complete remission <5 years
•Connective tissue or inflammatory disease
•Neurological / psychiatric disease (e.g., peripheral neuropathy, dementia, Parkisnon’s, epilepsy)
•Infection or pyrexial illness
•Uncontrolled thyroid disorders
•Renal impairment (e.g., glomerulus filtration rate less than 60)
•Liver disease

发起方

niversity of Auckland