Comparison of Extra Vascular Lung Water Index in Covid-19 ARDS and "Typical"ARDS Patients
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- 试验地点
- 1
- 主要终点
- Extravascular Lung Water Index
研究概览
简要总结
Covid-19 also primarily affects endothelium that line up the alveoli. The resulting hypoxemia may differ from "typical" Acute Respiratory Distress Syndrome (ARDS) due to maldistribution of perfusion related to the ventilation. Thus, pathophysiology of Covid-19 ARDS is different, which requires different interventions than typical ARDS. The investigators will assess whether extravascular lung water index and permeability of the alveolar capillary differs from typical ARDS with transpulmonary thermodilution (TPTD) technique. Extravascular Lung Water Index (EVLWI) and Pulmonary Vascular Permeability Index (PVPI) will be compared.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ARDS defined by Berlin Criteria longer than 24 hours
- •Undergoing mechanical ventilation
- •Noradrenaline demand >0.1 mcg/kg/min
排除标准
- •Not meeting ARDS criteria
- •Noninvasive mechanical ventilation
- •ARDS resolved shorter than 24 hours
- •Shock resolved
结局指标
主要结局
Extravascular Lung Water Index
时间窗: 1 day
The amount of fluid accumulated in the lung measured by transpulmonary thermodilution (ml/kg)
Pulmonary vascular permeability index
时间窗: 1 day
Integrity of the alveolocapillary barrier measured by transpulmonary thermodilution
次要结局
未报告次要终点
研究者
Olcay Dilken
Principal Investigator
Istanbul University - Cerrahpasa (IUC)