NCT01139307已完成不适用
Development of Novel Therapeutics for AMKL
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 主要终点
- Terminal differentiation
研究概览
简要总结
RATIONALE: Studying samples of blood or tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research study is studying biomarkers in samples from patients with Down syndrome and acute megakaryoblastic leukemia.
详细描述
OBJECTIVES:
- Determine whether megakaryocyte differentiation agents comprising a Rho kinase inhibitor and a JAK3 inhibitor can lead to proliferation arrest, polyploidization, and terminal differentiation of blasts in specimens from patients with Down syndrome and acute megakaryoblastic leukemia.
OUTLINE: Cryopreserved specimens are cultured and treated in vivo (in mice) and in vitro with megakaryocytic differentiation agents comprising a Rho kinase inhibitor and a JAK3 inhibitor.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Terminal differentiation
Proliferation arrest
Polyploidization
次要结局
未报告次要终点
研究者
相似试验
已完成
不适用
Biomarkers in Young Patients With NeuroblastomaNeuroblastomaNCT01169376Children's Oncology Group380
已完成
不适用
Resistance to Methotrexate in Patients With Acute Lymphoblastic Leukemia in Relapse or RemissionLeukemiaNCT00899899Children's Oncology Group135
进行中（未招募）
不适用
Studying Tissue and Blood Samples From Patients With Acute Myeloid LeukemiaLeukemiaNCT00900224Alliance for Clinical Trials in Oncology529
Unknown
不适用
Isotretinoin in Treating Young Patients With High-Risk NeuroblastomaNeuroblastomaNCT00939965Children's Cancer and Leukaemia Group75
招募中
不适用
DNA Analysis of Blood and Tissue from Patients with Lung CancerLung CancerNCT00471978Massachusetts General Hospital6,800