NCT03562715已完成不适用
Role of Mesenchymal Stem Cells Exosomes Derived microRNAs; miR-136, miR-494 and miR-495 in Pre-eclampsia Diagnosis and Evaluation
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 200
- 主要终点
- The expression of miRNAs 136, 494 and 495 in exosomes of peripheral blood and UCMSCs conditioned media
研究概览
简要总结
Pre-eclampsia is one of the most threatening pregnancy complications. So far neither a secure, competent therapy for PE nor effective biomarkers for a premature discovery has been achieved.The aim of our study was to identify miRNAs 136, 494 and 495 genes expression in exosomes of peripheral blood compared to umbilical cord mesenchymal stem cells conditioned media released exososomes in patients with PE, as valuable markers for PE early prediction.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 23 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •To have an uncomplicated pregnancy:
- •gestational age at venipuncture between 20 - 42 weeks
- •no medical, obstetrical, or surgical complications
- •absence of labor at the time of venipuncture
- •delivery of a normal term (≥ 37 weeks) neonate whose birth weight was between the 10th and 90th percentile for gestational age
排除标准
- •Patients with chronic hypertension, renal disease, and fetuses affected with congenital anomalies were excluded
结局指标
主要结局
The expression of miRNAs 136, 494 and 495 in exosomes of peripheral blood and UCMSCs conditioned media
时间窗: 2-3 months
次要结局
未报告次要终点
研究者
Nadine wagdi maurice
Teaching assistant at biochemistry department Faculty of pharmacy
Cairo University
相似试验
招募中
不适用
Exosome Cargo From Preeclampsia PatientsPreeclampsiaNCT04154332University of Alabama at Birmingham64
招募中
不适用
EV Based Platform for Monitoring Therapeutics Response During Pregnancy (ARISE)PreeclampsiaNCT06249178Ohio State University1,000
Unknown
1 期
Safety of Injection of Placental Mesenchymal Stem Cell Derived Exosomes for Treatment of Resistant Perianal Fistula in Crohn's PatientsPerianal Fistula in Patients With Crohn's DiseaseNCT05499156Tehran University of Medical Sciences80
招募中
不适用
New Therapeutic Strategy Against PreeclampsiaPreeclampsiaNCT06464159Assistance Publique - Hôpitaux de Paris100
招募中
不适用
Pilot Study of Microvesicles in Pre-eclamptic and Non-pre-eclamptic Women With Threatened Preterm DeliveryPre-EclampsiaNCT05675969University Hospital, Bordeaux20