Family Cohort Study on Primary Osteoporosis With Kidney-yang Deficiency Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 600
- 试验地点
- 3
- 主要终点
- changes in bone mineral density from baseline to 5 years after enrollment
研究概览
简要总结
Bone metabolism and genetic characteristics of osteoporosis pedigree with kidney-yang deficiency
详细描述
Families with or without osteoporosis of kidney-yang deficiency type will be included and compared with each other. Their genetic characteristics, bone changes, and TCM constitution are the focus of research.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Be able to cooperate with inspection.There is blood relationship between the members of the enrolled family.
排除标准
- •Unable to cooperate with inspection.There is not blood relationship between the members of the enrolled family.
结局指标
主要结局
changes in bone mineral density from baseline to 5 years after enrollment
时间窗: 5 years after enrollment
lumbar (L1-4 as well as total) and hip bone mineral density will be recorded by dual energy X-ray absorptiometry
Physical phenotype of traditional Chinese medicine
时间窗: 5 years after enrollment
Occurrence of kidney yang deficiency
Understand the general situation through the questionnaire
时间窗: 5 years after enrollment
Including age（year）, sex（man,wowan）, height(cm), weight(kg), menstrual period,history of smoking and drinking, living habits, fracture history and risk assessment, skeletal muscle assessment, living environment, Chinese medicine constitution, etc
次要结局
- Ca(5 years after enrollment)
- Osteocalcin(5 years after enrollment)
- procollagen type I N-terminal propeptide(at enrollment)
- Procollagen type I N-terminal propeptide(5 years after enrollment)
- Mg(5 years after enrollment)
- Parathormone(5 years after enrollment)
- Bone alkaline phosphatase(5 years after enrollment)
- β-crosslaps(5 years after enrollment)
- P(5 years after enrollment)
- Fibroblast growth factor(5 years after enrollment)
- 25(OH) vitamin D(5 years after enrollment)
- Gene testing(BGIseq T5,WGS)(5 years after enrollment)