Defining a Vascular Phenotype of Pancreatic Ductal Adenocarcinoma With CT Perfusion Using Quantitative Radiomics
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 125
- 试验地点
- 2
- 主要终点
- Correlation of CT-perfusion features with histopathological features
研究概览
简要总结
With CT-perfusion(CTP) it is possible to visualize the enhancement pattern of the tumor. The perfusion CT, interleaved with a routine contrast enhanced CT (CECT) will be performed at diagnosis in all patients (goal: n=125 patients) and at the first follow-up at 3 months in patients treated with systemic therapy (goal: n=50 patients). Also, the histopathology will be collected for resected tumors to perform histopathology analysis. CTP parameters will be correlated to immunohistological findings and clinical outcome.
The main goal of the study is to create an AI-assisted method to classify patients with a vascular phenotype of pancreatic ductal adenocarcinoma (PDAC). The investigators expect that this phenotype can be used to predict overall survival and chemotherapy response.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical suspicion of pancreatic cancer
- •18 years and older
- •written (signed and dated) informed consent
排除标准
- •Contra-indications to undergo CT (due to untreatable contrast allergy or renal function impairment)
- •Previous treatment for pancreatic cancer
- •Concomitant malignancies. Subjects with prior malignancies must be disease-free for at least 5 years
- •Insufficient command of the Dutch language to be able to understand the patient information
结局指标
主要结局
Correlation of CT-perfusion features with histopathological features
时间窗: Baseline, Time of Resection
To correlate the vascular phenotype with histopathologic features (stroma and microvessel density) in patients with pancreatic ductal adenocarcinoma
Classification of vascular phenotype using CT-perfusion
时间窗: Baseline
To classify a vascular phenotype with CTP using automated perfusion analysis in patients with pancreatic ductal adenocarcinoma
次要结局
- Association between survival and CT-perfusion features(Baseline, at 2 Years)
- Prediction of chemotherapy response(Baseline, 3 Months)
- Prediction of chemotherapy response compared to RECIST(Baseline, 3 Months, 6 Months)