Prevalence and Clinical Impact of Airway Opening Pressure in Post-Cardiac Surgery Patients: A Prospective Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 196
- 试验地点
- 1
- 主要终点
- Prevalence of significant airway opening pressure
研究概览
简要总结
Airway opening pressure is a key parameter in assessing respiratory mechanics. Current practice primarily relies on indirect assessments of lung mechanics, but growing evidence suggests that direct airway opening pressure measurement could enhance individualized ventilatory strategies. Significant airway opening pressure suggests incomplete alveolar recruitment at end-expiration, which may contribute to ventilation-perfusion mismatch, increased respiratory effort, and postoperative pulmonary complications such as atelectasis and impaired gas exchange. Determining the prevalence and clinical relevance of significant airway opening pressure in post-cardiac surgery patients could contribute to more personalized respiratory strategies and improve postoperative care.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Months 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult (≥18 years)
- •Undergoing elective coronary artery bypass grafting (CABG) or valve surgery, or combined procedures with expected postoperative mechanical ventilation
排除标准
- •- Patient receiving invasive mechanical ventilation prior to surgery
研究组 & 干预措施
Post operative cardiac surgery
干预措施: Airway opening pressure (Diagnostic Test)
结局指标
主要结局
Prevalence of significant airway opening pressure
时间窗: up to 1 hour after intensive care admission
airway opening pressure ≥ 5 cmH₂O
次要结局
- Airway opening pressure prevalence based on body mass index(up to 1 hour)
- Airway opening pressure prevalence based on cardiopulmonary bypass duration(up to 1 hour)
- Airway opening pressure prevalence based on left ventricular dysfunction(up to 1 hour)
- Airway opening pressure prevalence based on inotropic support(up to 1 hour)
- Airway opening pressure prevalence based on age(up to 1 hour)
- Airway opening pressure prevalence based on intraoperative fluid balance(up to 1 hour)
- Feasibility of airway opening pressure measurement(up to 1 hour)
- Positive end expiratory pressure level(up to 1 hour)
- Extubation(Day7)
- Patient position(up to 1 hour)
- Hemodynamic tolerance base on blood pressure drop(up to 15 minutes)
- Hemodynamic tolerance base on pulse oxygen saturation drop(up to 15 minutes)
- Non-interruptive airway opening pressure measurement method(up to 1 hour)
研究者
François Lellouche
Principal Investigator
Laval University