Correlation between Pulsatility Index in Transcranial Doppler and Post Stroke Outcomes in patients with Acute Lacunar Strokes
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- To determine whether changes in Pulsatility index in Transcranial Doppler correlates with post stroke outcome with respect to neurological deficits, disability and depression, following acute lacunar strokes
研究概览
简要总结
This is a prospective observational study to see how the presence and severity of deranged cerebral microvascular resistance (as indicated by the changes in Pulsatility Index in Transcranial Doppler) affects neuropsychological and functional recovery following acute lacunar strokes. Selected patients will be evaluated with Transcranial Doppler and baseline neurological deficits will be assessed by National Institute of Health Stroke Score(NIHSS), disability assessed by modified Rankin’s scale (mRS), and depression assessed by Beck’s depression Inventory-2 (BDI-2). These parameters will be reassessed at 3 months to see whether Pulsatility index at baseline can predict the functional and neuropsychological recovery following acute lacunar strokes.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 80.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients aged 18 to 80 years with acute or recent lacunar strokes (as per Trial of Organon Acute Stroke Treatment classification)
- •Evaluation within 2 weeks of stroke onset attending to Neurology, Stroke services, SCTIMST.
- •Imaging confirmation of acute lacunar stroke by MRI Brain.
排除标准
- •Age less than 18 or greater than 80 years.
- •Patients with evidence for large vessel atherosclerosis (greater than 50% stenosis of the extra or intracranial vessels with any of the imaging modalities)
- •Patients with large artery territory infarcts or major ICH at any point of time
- •Patients with prior psychiatric illness or cognitive impairment
- •Presence of heart failure, fever, respiratory distress or any other medical condition that can interfere with the neuropsychological assessment of the patient.
- •Impaired level of consciousness or significant aphasia.
结局指标
主要结局
To determine whether changes in Pulsatility index in Transcranial Doppler correlates with post stroke outcome with respect to neurological deficits, disability and depression, following acute lacunar strokes
时间窗: 0 and at 3 months
次要结局
- Not applicable(Not applicable)