Efficacy of Epidural Steroid in Controlling Postoperative Pain After Primary Total Knee Arthroplasty: A Randomized Double-blinded Controlled Trial
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 108
- 试验地点
- 1
- 主要终点
- post-operative pain
研究概览
简要总结
The purpose of this study is to determine efficacy of epidural steroid for postoperative pain control after TKA
详细描述
Epidural triamsinolone can reduce postoperative pain and longer duration of pain control after TKA
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 50 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •osteoarthritis of the knee who undergoing unilateral primary total knee arthroplasty
- •50-85 years old
- •ASA class 1-3
排除标准
- •unable to perform epidural anaesthesia
- •history of drug allergies: lidocaine, steroid
- •renal impairment (CrCl <30 mL/min)
- •liver impairment
- •cognitive function disorders
- •displacement of epidural catheter
研究组 & 干预措施
Epidural lidocaine
epidural lidocaine: 3 mL of 1% lidocaine with adrenaline and 3 mL of 1% lidocaine without adrenaline into epidural catheter at 48 hr after surgery
干预措施: epidural lidocaine (Drug)
epidural triamsinolone
epidural triamsinolone: 40 mg of triamsinolone (1 mL), 2.5 mL of 1% lidocaine with adrenaline and 2.5 mL of 1% lidocaine without adrenaline into epidural catheter at 48 hr after surgery
干预措施: epidural triamsinolone (Drug)
结局指标
主要结局
post-operative pain
时间窗: 3 months
measured with VAS for pain (VAS at rest and on motion)
次要结局
- functional knee score(3 months)
研究者
Supakit Kanitnate
orthopaedic department
Thammasat University