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临床试验/NCT03682861
NCT03682861Unknown不适用

Effect of Glycogen Replenishment on Time Trial Performance Following a Glycogen Lowering Exercise

Western University, Canada2 个研究点 分布在 1 个国家目标入组 15 人开始时间: 2018年9月30日最近更新:
适应症
干预措施

试验速览

阶段
不适用
发起方
入组人数
15
试验地点
2
主要终点
20 km time trial

研究概览

简要总结

Fifteen endurance-trained male/female will be randomly assigned to do four exercise and nutrition trials involving ingestion of four different concentrations of sweet corn derived starch (food component) in water (0, 1, 1.5 and 2 g. kg-1. h-1). Each trial will be separated by at least one week. During these four experimental trials athletes will be subjected to a glycogen-lowering cycling exercise protocol followed by a 4-h post-exercise recovery period (2h feeding then 2 hours of rest). At the end of 4-h period they will do a 20 kilometre time trial test on a stationary bike in a laboratory condition to measure the effect of different glycogen repletion rates on exercise performance.

详细描述

Post-exercise glycogen synthesis rate is an important factor in determining the time needed to recover. Glycogen synthesis is affected not only by the extent of glycogen depletion but also in a more direct manner by the type, duration, and intensity of the preceding exercise because these will differentially influence the acute enzymatic changes as well as recovery from the acute changes that are induced by strenuous exercise. To optimize glycogen synthesis rates, adequate amounts of carbohydrate should be ingested. It has been suggested initially that a carbohydrate intake of 0.35 g·kg body wt-1 ·h-1 , provided at 2-h intervals, maximized muscle glycogen synthesis. Others observed no differences in glycogen storage rates after subjects ingested 0.75 or 1.5 g carbohydrate·kg-1 · h-1 provided at 2-h intervals. In a follow-up study, it was reported that an intake of >0.5 g·kg-1 · h-1 is necessary to maximize post-exercise glycogen synthesis if supplements are administered at 2-h intervals. Higher glycogen synthesis rates have been reported in studies in which carbohydrates were ingested more frequently and at higher ingestion rates than in previous studies. Other efforts to increase glycogen synthesis rates by changing the form of administration (ie, as a solution, as a solid, or intravenously) have been unsuccessful. While the above range of intake rates has been suggested to maximize muscle glycogen resynthesis post-exercise, the required dosage with sweet corn derived high glycemic starch and its effect on a subsequent time trial exercise is currently unknown. So, investigators objective in this experiment is to find out optimal sweet corn derived recovery ingestion dose by using a glycogen lowering exercise protocol, followed by glycogen repletion via ingestion and a subsequent 20 km time trial cycling performance.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Single Group
主要目的
Other
盲法
Single (Participant)

盲法说明

Flavoured water placebo drink with no energy or carbohydrate drinks in opaque bottles to keep participant blinded

入排标准

年龄范围
18 Years 至 40 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • are a healthy male or female endurance athlete of 18- 40 years of age
  • have ≥2 y endurance training experience; training for ˃1 h/day

排除标准

  • Have symptoms or take medication for respiratory disease
  • Have symptoms or take medication for cardiovascular disease
  • Have symptoms or take medication for metabolic disease
  • Have symptoms or take mediation for neuromuscular disease
  • Use heart rate or blood pressure medications
  • Use any medications with side effects of dizziness, lack of motor control, or slowed reaction time
  • Have any cardiovascular or neuromuscular limitations to exercise
  • Are pregnant or find out that you are pregnant during experiment

研究组 & 干预措施

Placebo

Placebo Comparator

Placebo flavored drink similar to treatments but with no energy will be ingested post glycogen lowering exercise, followed by a 20 km time trial intervention

干预措施: 20 km time trial performance (Behavioral)

Placebo

Placebo Comparator

Placebo flavored drink similar to treatments but with no energy will be ingested post glycogen lowering exercise, followed by a 20 km time trial intervention

干预措施: Glycogen lowering exercise (Behavioral)

Carbohydrate drinks

Experimental

Sweet corn derived starch mixed in water at three different concentrations (6%, 12% and 18%) will be ingested post glycogen lowering exercise, followed by a 20 km time trial intervention

干预措施: 20 km time trial performance (Behavioral)

Carbohydrate drinks

Experimental

Sweet corn derived starch mixed in water at three different concentrations (6%, 12% and 18%) will be ingested post glycogen lowering exercise, followed by a 20 km time trial intervention

干预措施: Glycogen lowering exercise (Behavioral)

结局指标

主要结局

20 km time trial

时间窗: 40 minutes

participants will ride for 20 km on a stationary bike and time to finish will be measured

次要结局

  • VO2(2 hours)
  • Blood glucose(2 hours)
  • VCO2(2 hours)
  • Serum insulin(2 hours)
  • Blood lactate(2 hours)

研究者

发起方
Western University, Canada
申办方类型
Other
责任方
Principal Investigator
主要研究者

Peter Lemon

Professor

Western University, Canada

研究点 (2)

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