Study of Using Serum Fetuin-A as a Marker in Obesity and Type 2 Diabetes Mellitus
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 400
- 主要终点
- 1- Study of human serum fetuin-A and whether it is involved in insulin resistance
研究概览
简要总结
The aim of this study is to assess the significance of serum fetuin-A as a marker of obesity and type 2 diabetes mellitus. We used multiple statistical approaches to determine that the fetuin-A level is correlated to body mass index (BMI) as well as random blood sugar in type 2 diabetic patients. Also, we found that there is a Positive correlation between the serum fetuin-A levels and the level of glycosylated hemoglobin (HbA1c) in diabetic patients.
详细描述
The study was a case-control study. We started the study to be performed on eighty subjects divided into four groups:
The first group: include twenty subjects with type 2 diabetes mellitus The second group: include twenty obese subjects whose body mass index is 30 or over The third group: include twenty obese subjects with type 2 diabetes mellitus The fourth group includes twenty apparently healthy subjects as control.
In this study, we concluded that:
- Serum fetuin-A can be used as a biomarker and independent risk factor and marker for diagnosis of DM and DM has a detrimental effect on serum fetuin-A fetuin-A could be of relevance for the development of insulin resistance
- Higher fetuin-A concentrations were associated with type 2 diabetes and insulin resistance
- Increased serum fetuin-A levels constitute an independent marker of lipid profile.
- fetuin-A may play a role in the pathogenesis of T2DM.
- The inhibition of insulin receptor by fetuin-A may lead to increased lipolysis and efflux of free fatty acids from adipose tissue. This could explain associated dyslipidemia observed in type 2 diabetic patients in the present study.
Finally, our finding that high plasma fetuin-A levels predict the incidence of type 2 diabetes independently of other established risk factors supports the hypothesis that fetuin-A may play a role in the development of type 2 diabetes.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 45 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •• The study included obese and type 2 diabetic patients aged 45-60 years old. and control healthy adult persons
排除标准
- •• Cardiac disease and Hypertensive disease
- •Respiratory disease
- •Renal disease
- •GIT and Liver disease
- •Rheumatologic disease
- •Blood disease
- •Endocrine disease except for type 2 diabetes mellitus
- •All with a specific therapeutic drug history.
结局指标
主要结局
1- Study of human serum fetuin-A and whether it is involved in insulin resistance
时间窗: Baesline
2- To assess the significance of serum fetuin-A as a marker in obesity and type 2 diabetes mellitus
次要结局
未报告次要终点
研究者
Hosam Mohammad Ahmad
Dr.
Minia University