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临床试验/NCT02951832
NCT02951832Unknown不适用

Study About Lymphocytes Change During Menstrual Cycle in Women of Child-bearing Age

Shanghai First Maternity and Infant Hospital1 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2016年10月最近更新:
适应症

试验速览

阶段
不适用
入组人数
200
试验地点
1
主要终点
the percentage of lymphocyte subsets

研究概览

简要总结

The investigators are going to select the normal child-bearing period women as the study subjects and draw their peripheral blood to observe and analyze the change of quantity and percentage of lymphocyte subsets along with the change of menstrual cycle.

Recording their BMI\menstrual history\and childbearing history, the investigators would select 300 healthy women in 6 different age groups which are aged 20-24, aged 25-29, aged 30-34, aged35-39, aged 40-44 and aged 45-49, then draw 1-2 ml blood form their peripheral vein (adding EDTA for anti-coagulation). The investigators are going to perform routine examination on the blood samples and detect T\B\NK lymphocyte through flow cytometry (FCM), thus calculating the absolute number of every species of lymphocyte. The investigators make assessment for the cellular immune function of the women during child-bearing period via comparing distinction in percentage and absolute number of every lymphocyte subset among reproductive-age women in different ages.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
20 Years 至 49 Years(Adult)
性别
Female
接受健康志愿者

入选标准

  • Women aged 20-49;
  • Having a regular menstrual cycle of which the menstrual period is between day 3-7, and the period between day 25-35;
  • Excluding internal and surgical disease (after having variety of physical examination such as electrocardiogram/hepatic and renal function/blood routine and urine routine).

排除标准

  • Having experienced severe allergies, trauma history and/or operation history within 3 months;
  • With a history of mental illness and/or family history of mental illness;
  • Limb disabled;
  • Taking medicine within one month;
  • Suffering major events or having mood swings.

结局指标

主要结局

the percentage of lymphocyte subsets

时间窗: through study completion, an average of 1 year

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Shihua Bao

Principal Investigator

Shanghai First Maternity and Infant Hospital

研究点 (1)

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